University of Tennessee Health Science Center
Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
Abstract
dc:description.abstract<p>The pregnane X receptor (PXR or SXR; NR1I2) is a member of the nuclear receptor superfamily. It activates the transcription of a large network of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to adverse drug-drug interactions. Non-toxic, PXR-specific antagonists will be valuable in attenuating the adverse drug-drug interaction which is the cause of many treatment failures in clinic. However, few hPXR antagonists were reported particularly the specific ones. In this thesis a reporter gene assay was used to study the specificity of hPXR antagonists from a panel of compounds that have been previously indentified as non-toxic hPXR antagonists.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (MS)
- Level thesis:degree_level
- Thesis
- Discipline thesis:degree_discipline
- Biomedical Sciences
- Year dc:date.available
- 2009
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Lei, Fang
- Contributors dc:contributor
-
- Taosheng Chen, Ph.D.
Subjects
dc:subject × 4Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.uthsc.edu/dissertations/143
- OAI identifier oai:identifier
- oai:dc.uthsc.edu:dissertations-1149