Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Cancer Growth"”.
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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
… Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in three different breast cancer cell lines with lincRNA-p21 knockdown. Mechanistically, we found that lincRNA-p21 …
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Micrornas That Affect Breast Cancer Growth, Metastasis And Estrogen-Independent Growth
… I: MICRORNA-205 IS A TUMOR SUPPRESSOR IN BREAST CANCER Major Professor: Dr. Yinyuan Mo MicroRNAs as a class of novel negative regulators have drawn intensive attention since their existence in mammals was discovered in 2001. As endogenous small non-coding RNAs, miRNAs are capable of silencing …
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Imbalance Between Neutrophil Elastase and Elafin Promotes Breast Cancer Growth and Progression
… has tumor suppressive properties in breast cancer. In support of this hypothesis, immunohistochemical (IHC) analysis revealed that elafin was downregulated in the majority of invasive breast tumors and a subset of pre-invasive ductal carcinoma <em>in situ </em>(DCIS) compared to elafin …
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Anti-Insulin Resistance Treatments Suppress Her2+ Breast Cancer Growth Via Altering Metabolism
… a significant risk factor for carcinogenesis and cancer death, including breast cancer. Our previous finding in patients showed that anti-insulin resistance treatments are associated with improved HER2<sup>+</sup> breast cancer survival of diabetic women. However, there were no transgenic mouse …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… tumours that are deemed to be made up of cancer cells and it is this process of invasion that defines them and will be studied in this thesis.<br/><br/>We do this by considering two scales of interest in cancer cell invasion. In Chapters 4 and 5, we focus on tissue scale dynamics of a …
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Mathematical Modelling of Cancer Growth and Development: Adhesion, Stem Cells and Structure
… has investigated some of the intricacies of the growth and development of a solid tumour. Mathematical models and biological experimentation were used to gain a better understanding of the dual roles that the proto-oncogenic protein β-catenin has in adhesion and transcription, as well as its …
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RESVERATROL INHIBITS PROSTATE CANCER GROWTH AND METASTASIS BY TARGETING AKT/MICRORNA-21 PATHWAY
Prostate cancer is the most commonly diagnosed cancer and the second most leading cause of cancer deaths in American men (www.cancer.org). Most prostate cancer-related deaths are due to the metastatic form of the disease. The 5-year relative survival rate in patient's diagnosed with metastatic …
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A novel regulatory role of leucyl-tRNA synthetase in supporting human cancer growth
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
… significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 nM Ang-(1-7) in vitro, supporting the anti-proliferative properties of the heptapeptide. Mas was detected by Western blot hybridization in both cell types.
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
Pathways underlying metabolic reprogramming in cancer remain incompletely understood. We identified the Transmembrane Serine Protease TMPRSS11B as a novel gene that promotes transformation of immortalized human bronchial epithelial cells. TMPRSS11B is upregulated in human lung squamous cell cancers …
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The Role of The Diras Family Members In Regulating Ras Function, Cancer Growth and Autophagy
… for its tumor suppressive function in ovarian cancer. By assessing the structure-function relationship, I found that DIRAS3 inhibits Ras-induced transformation and is a natural antagonist of Ras/MAPK signaling. DIRAS3 binds directly to Ras and disrupts cluster formation inhibiting the …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
Breast cancer (BC) is the most commonly diagnosed cancer in women, the leading cause of cancer death in females worldwide, and the second in American women (after lung cancer) according to CDC. In the most advanced stage of BC, stage IV, cancer cells metastasize from the original site to distant …
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Synthesis of unnatural analogues of pancratistatin and narciclasine
… discussed. Evaluation of the new analogues as cancer growth inhibitory agents is also described
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
<p>Breast cancer is the most common type of cancer among women in the US. Phytoestrogen resveratrol (RS V) has been described as a potential ehemotherapeutic agent, but has been associated with breast cancer cell growth and cell death. RSV binds to estrogen receptors (ER) and functions as a mixed …
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The Role and Mechanism of Enhanced Met Expression in Pancreatic Cancer
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States annually and little progress has been made in the past 30 years to improve patient survival. Therefore, it is imperative the signaling pathways that drive pancreatic cancer growth and progression be identified and …
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Dietary vitamin B6 supplementation promotes the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague Dawley rats
… receptor - positive and - negative breast cancer cells is growth inhibitory. Others have reported that dietary B6 supplementation resulted in increased fibrosarcoma pyridoxal phosphate (PLP) concentrations and a significant inverse relationship between tumor PLP concentration and tumor …
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Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors
… (SphK) has emerged as an attractive target for cancer therapeutics due to its role in cell proliferation. SphK phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) which has been implicated as a major player in cancer growth and survival. SphK exists as two different isoforms, namely …
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A general method for studying autocrine signaling and its impact on cancer cell growth
… essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine has been limited to cancer tissues with adequately characterized mitogenic pathways. Its …
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Multiscale Mathematical Modelling of Cancer Invasion
… surrounding tissue is one of the hallmarks of cancer. Solid tumours have a reciprocal relationship with the surrounding microenvironment, a complex tissue composed of extracellular matrix and other multiple distinct cell types. Prote- olytic degradation and remodelling of the extracellular …
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Geographical health data maps for Carle Foundation Hospital and the assessment of rural cancer rates in Illinois
Cancer is the second leading cause of death in the United States and in the state of Illinois. With numerous research efforts put into finding the causes of cancers, many genomic cancer risk factors have been confirmed, e.g. the importance of HER2 gene in breast cancer growth. However, how the …
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