Mathematical Modelling of Cancer Growth and Development: Adhesion, Stem Cells and Structure

This thesis has investigated some of the intricacies of the growth and development of a solid tumour. Mathematical models and biological experimentation were used to gain a better understanding of the dual roles that the proto-oncogenic protein β-catenin has in adhesion and transcription, as well as its involvement in the epithelial-mesenchymal transition. Emphasis was placed on the spatial location of β-catenin within cells to determine what function it is performing. A model was also created to explore the hypothesis that multiple forms of β-catenin exist within cells to perform separate functions. The cancer stem cell hypothesis was explored in solid tumour growth, without necrosis and angiogenesis, by the use of a discrete, cell-based model created with the software package CompuCell3D. This was compared to a novel continuum model, which can be used to perform in silico experiments of solid tumours with a stem-progenitor-mature cell structure for a biologically relevant number of cells. Lastly, a cell-based model of a solid, vascularised tumour was created in CompuCell3D to investigate how an age- and size-structured population of cells can affect the overall growth of the tumour. This model was also used to show how the age structure of cells in a solid tumour can affect the efficacy of chemotherapeutic treatments.

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

University of Dundee

Year dc:date.issued

2014

Author dc:creator

• Kelly, John

Advisor dc:contributor.advisor

• Nathke, Inke

Language dc:language

eng

Identifier

oai:discovery.dundee.ac.uk:studenttheses/94ea4aba-556e-4b08-a62e-a5000ce8bfe3

OAI identifier oai:identifier

oai:discovery.dundee.ac.uk:studenttheses/94ea4aba-556e-4b08-a62e-a5000ce8bfe3