Synthesis of unnatural analogues of pancratistatin and narciclasine

Described herein is the chemoenzymatic synthesis of several different types of unnatural analogues of Amaryllidaceae constituents. Development and refinement of existing and design and execution of new approaches towards the synthesis of C-1 analogues of pancratistatin and A-ring heterocyclic analogues of narciclasine are discussed. Evaluation of the new analogues as cancer growth inhibitory agents is also described

Name thesis:degree_name

Ph.D. Chemistry

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Faculty of Mathematics and Science

Department dc:contributor.department

Department of Chemistry

Grantor

Brock University

Year dc:date.issued

2014

Author dc:creator

• Vshyvenko, Sergey

• total synthesis
• Amaryllidaceae
• anticancer
• Biotransformation

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/10464/5434

OAI identifier oai:identifier

oai:brocku.scholaris.ca:10464/5434