Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"CD1a"”.
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Ex-vivo Untersuchungen zur Arzneimittelwirkung topischer Tacrolimus (FK-506) Anwendung auf epidermale dendritische Zellen in läsionaler Haut bei Patienten mit atopischem Ekzem
… of topical tacrolimus treatment on epidermal CD1a+/FcepsilonRI+ DC populations in lesional AD. METHODS: Immunohistological analysis, epidermal DC phenotyping, and functional studies were performed on skin biopsy specimens from treated and untreated lesional skin of 10 patients with AD …
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Experimentelle Untersuchungen zur zellbiologischen Charakterisierung Inflammatorischer Dendritischer Epidermaler Zellen in entzündlich veränderter Epidermis
… Außerdem konnte gezeigt werden, daß die CD1a- Expression der MoDC mit längerer Kulturdauer stärker wird, und daß eine Zugabe von autologem Serum in die Kultur diese Ausreifung von Monozyten zu MoDC hemmt. Der zweite Teil dieser Arbeit befasste sich mit vergleichenden …
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Σύγχρονα δεδομένα για τη διάγνωση και θεραπεία της ιστιοκύττωσης Langerhans / Current concepts for the diagnosis and management of Langerhans cell histiocytosis
… νόσος χαρακτηρίζεται από κλωνικό πολλαπλασιασμό CD1a+/CD207+ δενδριτικών κυττάρων μυελικής προέλευσης και προσβάλλει συχνότερα τα οστά, το δέρμα, τους πνεύμονες, το ενδοκρινικό σύστημα και το κεντρικό νευρικό σύστημα. Τα τελευταία χρόνια, η πρόοδος στη μοριακή βιολογία έχει οδηγήσει σε ουσιαστική …
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Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus
… stains (p24, p16, pRb, E-cadherin, CD1a, Langerin, Bcl-2, Ki-67, HPV L1 capsid protein and β-catenin) were performed and scored in normal, dysplastic and carcinomatous tissue. Data were analysed to determine if there were statistically significant differences in the expression of …
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Erweiterung eines diagnostischen Verfahrens zur Differenzierung entzündlicher Dermatosen mittels Immunphänotypisierung dendritischer Zellen der Epidermis
… Mikromilieu im Phänotyp der immunkompetenten CD1a positiven epidermalen dendritischen Zellpopulation widerspiegelt, wurde seit 1995 ein Verfahren zur Immunphänotypisierung von Langerhans Zellen und IDEC entwickelt. Es konnte gezeigt werden, dass das atopische Ekzem durch eine hohe Expression …
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Deficiência de arginina-vasopressina (diabetes insipidus central) como primeira manifestação de histiocitose de células de Langerhans: relato de caso
… system characterized by proliferation of CD1a⁺/Langerin⁺ myeloid dendritic cells and activating mutations in the MAPK/ERK pathway (such as BRAF V600E and MAP2K1). Involvement of the hypothalamic–pituitary axis occurs in up to 30% of cases, presenting as arginine-vasopressin (AVP) …
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Clinical and Histopathological Characteristics of Nevus Depigmentosus
… antibodies to S-100 protein, MART-1, GP-100, CD1a, CD3, CD20, and CD68. RESULTS: The lesions were usually present before the age of 3 years (68.3%), but some lesions appeared later in childhood (31.7%). Twenty seven patients (45.0%) had one lesion, but there were 14 patients (23.3%) who had …
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Studies of Non-Classical Antigen Presentation Molecules: Functional Analysis of Mouse Qa-1 and Characterization of the Porcine CD1 Gene Family
… that pCD1.1 is most closely related to human CD1A. Emergence of pCD1.1 was earlier than CD1E and later than CD1C, based on branching order. Porcine pCD1.1 mRNA was expressed in CD3$\sp-$ thymocytes and professional antigen presenting cells (APCs). Together, the unique structure and expression …
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IL-23 and IL-27 expression in dendritic cells and the effects of HIV-1
… resulting from elective abdominoplasties by CD1a and CD1c microbeads. Circulating DCs were isolated from peripheral blood by CD1c microbeads. As an experimental model, monocyte-derived DCs (MDDCs) were generated from freshly isolated monocytes which were cultured for 6 days with IL-4 and …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… subsets were characterized using CD45, CD207, CD1a, CD11c, CD14, CD3, HLA-DR, CD80/86, CD209, CD206, CD169, CD4 and CCR5. Results: Foreskin myeloid cells contained a rare population of LCs (1.11 % ± 1.02 %;) that was predominantly migratory (p = 0.0084) and “macrophage-like” cells (9.87 % ± …
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Defining interactions between Mycobacterium leprae and Langerhans cells
… that M. leprae antigens can be presented via CD1a on Langerhans cells has spurred interest in understanding how Langerhans cells interact and uptake M. leprae leading to downstream effects on T cell activation and overall immune responses. The hypothesis of this study is that M. leprae …
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New Aspects of Alveolar Adaptive Immune Responses in COPD
… increase in DC subsets, including BDCA-2+, CD1a+langerin- and CD11c+CD68-CD163- DCs, was observed in the alveolar tissue. Notably, the DCs in LA interfaces and alveolar tissue differed from airway DCs by a distinct marker expression profile. The 3D analysis revealed an intricate connection …
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Characterizing various aspects of the male genital tract barrier function and immunity
… Elite microscope, the density of CD4+CCR5+, CD1a+ cells, and percent claudin-1 expression were analyzed in 144 male participant foreskin tissue samples from a randomized on-demand pre-exposure prophylactic clinical trial. Results The overall prevalence of asymptomatic STIs was 15.9%, where …
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Characterization of human foreskin Langerhans cells
… and immune-profiled by flow cytometry. CD1a and CD207 were used to identify Langerhans cells while HLA-DR, CD80, CD86 and CD40 were used as markers of maturity and activation. The gene expression profile of sorted LCs was also examined by single-cell sequencing with seq-well. Lastly, the …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
The present study examined adverse effects of sunlight exposure (mimicked by intradermal cis-urocanic acid, cUCA) on local and systemic immune responses, with or without co-exposure to the immunotoxic insecticide permethrin. A single exposure to cUCA caused diminished splenic macrophage …