Clinical and Histopathological Characteristics of Nevus Depigmentosus

PURPOSE: Nevus depigmentosus (ND) is known to be a rare congenital, nonprogressive disorder characterized by hypopigmented lesion that remains stable over time. There have been only few studies of clinical and histopathological characteristics of ND, and the etiopathogenesis is not fully established. The purpose of this study was to investigate the clinical and histopathological characteristics of ND. MATERIALS AND METHODS: A clinical survey was carried out with 60 patients diagnosed as having ND. Two millimeter punch biopsies from lesional and perilesional normal skin were done. The sections were stained with hematoxylin-eosin, Fontana-Masson, antibodies to S-100 protein, MART-1, GP-100, CD1a, CD3, CD20, and CD68. RESULTS: The lesions were usually present before the age of 3 years (68.3%), but some lesions appeared later in childhood (31.7%). Twenty seven patients (45.0%) had one lesion, but there were 14 patients (23.3%) who had more than ten lesions. Fontana-Masson stain showed that the amount of melanin was significantly decreased in ND skin compared with perilesional normal skin. Melanocyte counts were significantly decreased in ND skin when stained with antibodies to GP-100 and MART-1. However, there were no significant differences in the number of melanocytes identified as S-100 protein positive cells. There were no significant differences in histologic findings or dermal inflammatory infiltrates between ND skin and perilesional normal skin. CONCLUSION: Only 18 patients (30.0%) presented with ND at birth and only 27 patients (45.0%) had 1 lesion. Both the amount of melanin and the number of melanocytes in ND skin were decreased in patients with ND. However melanin and melanocytes may also be present in vitiligo skin. Therefore, both clinical and histologic findings should be considered together to make a diagnosis of ND.

Author dc:creator

• 김, 성권

Contributors dc:contributor

• 김, 유찬
• 대학원 의학과
• 200424166

• 탈색모반

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001109
000000001109

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1443