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Showing 1 to 20 of 30 for “"Antithrombin"”.

  1. Präpartale Veränderungen in der Aktivität des Antithrombin III und der Konzentration des Thrombin-Antithrombin III bei Schwangerschafts-induzierter Hypertonie und Präeklampsie

    Buchta, Christof1998

    aachen Repository record

  2. A peptide model for the heparin binding site on Antithrombin III

    Lellouch, Annemarie Coffman.Massachusetts Institute of Technology1992

    Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1992

    mit Repository record

  3. MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS

    KRISHNASAMY, CHANDRAVEL2014

    … positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific …

    vcu Repository record

  4. Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins

    Kjellberg, MargaretaDepartment of Laboratory Medicine, Lund University2007

    Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result …

    lund Repository record

  5. Isolierung und Charakterisierung von Endothelzelloberflächen-Heparansulfat (ES-HS) und seiner funktionellen Domänen für die Interaktion mit Gewebeplasminogen-Aktivator (t-PA) und Antithrombin III (AT III)

    Windmüller, Ursula1996

    aachen Repository record

  6. The Effect of Acute Exercise on Coagulation Factors and the Mechanical Properties of Fibrin Fibers

    Holland, Georgia CarrollWake Forest University2016

    … alpha-2- antiplasmin (p= .018, ɲ2= .552), antithrombin (p= .026, ɲ2= .481), and fibrin fiber extensibility (p= .003, ɲ2= .691). A significant increase in platelet levels was seen within groups from pre- to post-exercise (p= .048, ɲ2= .507). Pearson’s correlations revealed significant …

    wfu Repository record

  7. Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants

    Henry, Brian Lawrence2014

    … FIXa, and FVIIa in the presence and absence of antithrombin. CDs and FDs display a preference for direct inhibition of thrombin and FXa, and exhibit a high level of specificity over FIXa and FVIIa. In the presence of AT, CDs and FDs displayed weaker inhibition of FXa and thrombin suggesting that …

    vcu Repository record

  8. The Effects of Prednisone and Prednisone Plus Ultralow-dose Aspirin on Coagulation Parameters in Healthy Dogs

    O'Kell, Allison LouiseVirginia Tech2012

    … Ly30 (percent lysis 30 minutes after MA) and antithrombin activity significantly decreased within each group. For the prednisone plus placebo group, Ly60 (percent lysis 60 minutes after MA) significantly decreased from baseline. For all parameters, there was no difference between groups for …

    vt Repository record

  9. Designing Direct and Indirect Factor Xa Inhibitors

    Al-Horani, Rami2017

    … (THIQ) nonsaccharide allosteric antithrombin activators was designed, synthesized, and biochemically evaluated to establish their structure–activity relationship (SAR). An N–arylacyl THIQ analog having carboxylate at position–3, two sulfate groups at positions–5 and –8 of THIQ …

    vcu Repository record

  10. Evaluation of hemostasis in hyperthyroid cats

    Keebaugh, Audrey ElizabethVirginia Tech2020

    … partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), D-dimers, thrombin-antithrombin complexes (TAT), von Willebrand Factor antigen (vWF:Ag), and activity of factors VIII and IX were measured. An echocardiogram was performed in all cats and healthy cats with abnormal echocardiograms …

    vt Repository record

  11. Compositional Determinants of the Pharmacological Actions of Heparins

    Gray-Shah, Angel Lee1970

    … blood coagulation via their plasmatic cofactors antithrombin (AT) and heparin cofactor II (HCII).</p><p>In these studies, various heparins with molecular weights ranging from 2.6 to 16.5 kDa were investigated. Not only the molecular weight but also the oligosaccharide composition greatly varied …

    loyola-thes Repository record

  12. Structure-activity relationships of PAI-1 inhibitors

    Sanders, Karen2012

    … low affinity, inhibit the serpin plasma protein antithrombin III, and/or fail to inhibit PAI-1 when vitronectin, a cofactor of PAI-1 is present. The synthesis of small-molecule inhibitors of PAI-1 that improve upon these properties has been the main goal of this research. Research efforts focused …

    emich Repository record

  13. Construction of comparative and framework linkage maps for the identification of quantitative trait loci in cattle

    Beever, Jonathan EdwardUniversity of Illinois at Urbana-Champaign2011

    … alkaline phosphatase (ALPL), amylase 1 (AMY1), antithrombin III (AT3), Gardner-Rasheed feline sarcoma (v-fgr) oncogene homolog (FGR), alpha-L-fucosidase 1 (FUCA 1), interleukin 10 (1L10), myogenin (MYOG), phoshogluconate dehydrogenase (PGD), and the $\beta$ subunit of thyroid stimulating hormone …

    uiuc Repository record

  14. Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives

    Oluwagbemiga, Osunsanmi FolusoUniversity of Zululand2015

    … hydrolysis of chromogenic substrate was used for antithrombin activity of the triterpenoids. The release of ATP and calcium mobilization from the cytosol, as platelets aggregate, was investigated using a commercial kit and Fura 2/AM respectively. The anti-acetylcholinesterase activity of the …

    zulu Repository record

  15. Perioperative Veränderungen der Hämostase bei langdauernden onko-gynäkologischen Operationen

    Knippenberg-Bigge, KatrinPublikationsserver der RWTH Aachen University2001

    … (PT), thrombin time (TT), fibrinogen, D-dimer, antithrombin III and fibrin monomer. All patients showed signs of haemostatic abnormality. Preoperatively, compensated DIC with signs of hypercoagulation were evident. Postoperatively, DIC with micro- and macrothrombosis and bleeding, which …

    aachen Repository record

  16. Antithrombotic and anti-inflammatory activity of ethyl acetate extract of Protorhus longifolia stem bark

    Majola, Londiwe CynthiaUniversity of Zululand2019

    … chromogenic substrate was used to determine the antithrombin activity of the extract. While the thrombolytic activity of the extract was determined in rat whole blood clot, the antiplatelet aggregation activity was evaluated on rat platelet rich plasma. The carrageenan induced rat paw edema and …

    zulu Repository record

  17. Biokompatibilitätsuntersuchungen an Originaldialysatoren in einem In-vitro-Dialyse-Rezirkulationsmodell unter besonderer Berücksichtigung von Faktor XIIa-C1-Inhibitor, einem Marker für die Aktivierung des Kontaktphasensystems

    Geerkens, ThomasPublikationsserver der RWTH Aachen University2006

    … parameters was investigated. Thrombin-antithrombin complex (TAT), platelet loss, platelet factor 4 and C5a were measured to detect activation of the coagulation cascade, platelet activation and complement activation.The contact system is generally believed to be the main trigger of the …

    aachen Repository record

  18. Novel tools for sequence and epitope analysis of glycosaminoglycans

    Behr, Jonathan RobertMassachusetts Institute of Technology2007

    … with protamine to quantify total HSGAGs or with antithrombin-III (AT-III) to quantify a specific anticoagulant epitope.

    mit Repository record

  19. Elimination von Danaparoid mittels Filtration : Bestimmung der Eliminationskinetik in physiologischer Kochsalzlösung, Humanalbumin und humanem Vollblut

    Schneider, Katja Susanne Annika

    … von Danaparoid beruht vorwiegend auf der Antithrombin-induzierten Hemmung des aktivierten Faktors X. Durch den Einsatz bei der Heparin-induzierten Thrombozytopenie gewann Danaparoid seine besondere Bedeutung. <br>Danaparoid wird renal eliminiert. Bei Patienten mit eingeschränkter …

    freiburg-diss Repository record

  20. Development of novel analytical tools for complex carbohydrates

    Keiser, Nishla, 1978-Massachusetts Institute of Technology2004

    … known specificity (fibroblast growth factor and antithrombin III), then utilized the technique to identify an oligosaccharide binder for a protein with unknown HSGAG binding specificity (endostatin). Furthermore, this technique can be readily applied to carbohydrate material from the cell …

    mit Repository record

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