Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Antithrombin"”.
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A peptide model for the heparin binding site on Antithrombin III
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1992
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MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS
… positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific …
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Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins
Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result …
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The Effect of Acute Exercise on Coagulation Factors and the Mechanical Properties of Fibrin Fibers
… alpha-2- antiplasmin (p= .018, ɲ2= .552), antithrombin (p= .026, ɲ2= .481), and fibrin fiber extensibility (p= .003, ɲ2= .691). A significant increase in platelet levels was seen within groups from pre- to post-exercise (p= .048, ɲ2= .507). Pearson’s correlations revealed significant …
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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants
… FIXa, and FVIIa in the presence and absence of antithrombin. CDs and FDs display a preference for direct inhibition of thrombin and FXa, and exhibit a high level of specificity over FIXa and FVIIa. In the presence of AT, CDs and FDs displayed weaker inhibition of FXa and thrombin suggesting that …
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The Effects of Prednisone and Prednisone Plus Ultralow-dose Aspirin on Coagulation Parameters in Healthy Dogs
… Ly30 (percent lysis 30 minutes after MA) and antithrombin activity significantly decreased within each group. For the prednisone plus placebo group, Ly60 (percent lysis 60 minutes after MA) significantly decreased from baseline. For all parameters, there was no difference between groups for …
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Designing Direct and Indirect Factor Xa Inhibitors
… (THIQ) nonsaccharide allosteric antithrombin activators was designed, synthesized, and biochemically evaluated to establish their structure–activity relationship (SAR). An N–arylacyl THIQ analog having carboxylate at position–3, two sulfate groups at positions–5 and –8 of THIQ …
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Evaluation of hemostasis in hyperthyroid cats
… partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), D-dimers, thrombin-antithrombin complexes (TAT), von Willebrand Factor antigen (vWF:Ag), and activity of factors VIII and IX were measured. An echocardiogram was performed in all cats and healthy cats with abnormal echocardiograms …
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Compositional Determinants of the Pharmacological Actions of Heparins
… blood coagulation via their plasmatic cofactors antithrombin (AT) and heparin cofactor II (HCII).</p><p>In these studies, various heparins with molecular weights ranging from 2.6 to 16.5 kDa were investigated. Not only the molecular weight but also the oligosaccharide composition greatly varied …
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Structure-activity relationships of PAI-1 inhibitors
… low affinity, inhibit the serpin plasma protein antithrombin III, and/or fail to inhibit PAI-1 when vitronectin, a cofactor of PAI-1 is present. The synthesis of small-molecule inhibitors of PAI-1 that improve upon these properties has been the main goal of this research. Research efforts focused …
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Construction of comparative and framework linkage maps for the identification of quantitative trait loci in cattle
… alkaline phosphatase (ALPL), amylase 1 (AMY1), antithrombin III (AT3), Gardner-Rasheed feline sarcoma (v-fgr) oncogene homolog (FGR), alpha-L-fucosidase 1 (FUCA 1), interleukin 10 (1L10), myogenin (MYOG), phoshogluconate dehydrogenase (PGD), and the $\beta$ subunit of thyroid stimulating hormone …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… hydrolysis of chromogenic substrate was used for antithrombin activity of the triterpenoids. The release of ATP and calcium mobilization from the cytosol, as platelets aggregate, was investigated using a commercial kit and Fura 2/AM respectively. The anti-acetylcholinesterase activity of the …
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Antithrombotic and anti-inflammatory activity of ethyl acetate extract of Protorhus longifolia stem bark
… chromogenic substrate was used to determine the antithrombin activity of the extract. While the thrombolytic activity of the extract was determined in rat whole blood clot, the antiplatelet aggregation activity was evaluated on rat platelet rich plasma. The carrageenan induced rat paw edema and …
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Novel tools for sequence and epitope analysis of glycosaminoglycans
… with protamine to quantify total HSGAGs or with antithrombin-III (AT-III) to quantify a specific anticoagulant epitope.
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Elimination von Danaparoid mittels Filtration : Bestimmung der Eliminationskinetik in physiologischer Kochsalzlösung, Humanalbumin und humanem Vollblut
… von Danaparoid beruht vorwiegend auf der Antithrombin-induzierten Hemmung des aktivierten Faktors X. Durch den Einsatz bei der Heparin-induzierten Thrombozytopenie gewann Danaparoid seine besondere Bedeutung. <br>Danaparoid wird renal eliminiert. Bei Patienten mit eingeschränkter …
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Development of novel analytical tools for complex carbohydrates
… known specificity (fibroblast growth factor and antithrombin III), then utilized the technique to identify an oligosaccharide binder for a protein with unknown HSGAG binding specificity (endostatin). Furthermore, this technique can be readily applied to carbohydrate material from the cell …
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Erstellung und Erprobung eines wissensbasierten Systems zur Unterstützung der Labordiagnostik der Thrombophilie
… <br><br>Das Alter und Geschlecht der Patienten, Antithrombin III, Quick, aktivierte partielle Thromboplastinzeit, Protein C, Protein S, Resistenz gegen akt. Protein C (APCR), Faktor V-Mutation, Faktor II-Mutation, Lupus Antikoagulans, Cardiolipin-Antikörper und Heparin assoziierte Antikörper …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… to HSPG protein cores through HS profiling and antithrombin-Ab staining, revealing the aberrant enrichment of a unique sulfated tetrasaccharide (Tetra-1) in PDAC tissues from KRAS<sup>G12D</sup>-driven PDAC genetically engineered mice model but not in healthy pancreas from WT-KRAS mice. HS3ST1, …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
… delivered but not when coadministered with an antithrombin agent heparin. Heparin also reduced MSC-associated in situ thrombosis incorporating platelets and VWF in the microvasculature. Heparin-assisted MSC delivery reduced acute apoptosis and significantly improved infarct size, left …
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Psychological, cardiovascular and haematological aspects of the type A behaviour pattern in relation to coronary heart disease
… with the greater increase in the anticoagulant, antithrombin III. The complexity of these haenatological findings encouraged the examination of two prostaglandins which control platelet function (the coagulatory thromboxane A2 , and the anticoagulatory prostacyclin). Different response patterns …
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