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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Active pharmaceutical ingredient (API )"”.
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Improvement of cleaning effectiveness through Statistical Process Control in active pharmaceutical ingredient (API) manufacturing
… the effectiveness of cleaning processes at an active pharmaceutical ingredient (API) manufacturing site that was in the phase of engineering trials and cleaning cycle development. Cleaning cycles executed on the site prior to the project were found to be inconsistent in cleaning the equipment …
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Methods for Increasing Sensitivity and Throughput of Solid-State NMR Spectroscopy of Pharmaceutical Solids
… structure, and dynamics of a pure or formulated active pharmaceutical ingredient (API). To overcome the major shortcomings of SSNMR, acquisition time and sensitivity, a two-sample probe was designed, developed, and tested. The probe allowed for two samples to be acquired simultaneously while …
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Effects of API particle size on the dissolution rate in molten polymer excipient matrices during hot melt extrusion, conducted in a co-rotating twin-screw extruder
The effect of the Active Pharmaceutical Ingredient (API) particle size on the dissolution rate in the polymer excipient during hot melt extrusion is investigated using a co-rotating twin-screw extruder with three different screw configurations. Acetaminophen (APAP) and amphiphilic polyvinyl …
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Theoretical and experimental investigation of particle interactions in pharmaceutical powder blending
In pharmaceutical manufacturing practices, blending of active pharmaceutical ingredient (API) with excipients is a crucial step in that homogeneity of active ingredient after blending is a key issue for the quality assurance of final products. Inadequate knowledge of the interdependence between raw …
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Preparation of nanovehicles for targeted drug delivery
Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective …
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Co-crystal screening of poorly water-soluble active pharmaceutical ingredients. Application of hot stage microscopy on curcumin-nicotinamide system and construction of ternary phase diagram of fenbufen-nicotinamide-water co-crystal system.
… compound suffers from poor bioavailability and rapid neutral-alkaline degradation. Co-crystal of curcumin is one option under exploration, motivated by the fact that a number of active pharmaceutical ingredient (API) co-crystals with improved dissolution have recently been synthesized. Hence, …
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Design of a small-scale continuous linear motion pharmaceutical filtration module
A new small-scale continuous linear motion pharmaceutical filtration prototype was designed, fabricated, and tested. The goal of this unit is to filter an Active Pharmaceutical Ingredient (API) from a mixture of API molecules, ethyl acetate, and possible contaminants. This unit is important in the …
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An investigation of the potential for and application of life cycle analysis in the pharmaceutical industry
… have been made to apply this method to the pharmaceutical industry. The Toxic Release Inventory is a powerful tool to determine areas of high potential for emissions reductions in industry. When applied to the pharmaceutical industry and coupled with a life cycle assessment, areas for …
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Study of controlled release of dapsone from modified montmorillonite and polymer matrices
… release system of Dapsone (DAP) as the Active Pharmaceutical Ingredient (API) intercalated into sodium montmorillonite (MMT-Na+) and their combination with an anionic copolymer (Eudragit S100). The effects of the excipients on the API dissolution rate were studied from their release …
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Inventory modeling for active pharmaceutical ingredient supply chains
Pharmaceutical companies traditionally manufactured drugs in-house, and have only recently been increasingly outsourcing production to contract manufacturing organizations (CMOs). In this work, we use inventory modeling to explore the trade-off between the attractive purchase price and the hidden …
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Desenvolvimento de antisséptico bucal em pastilha para prevenção da cárie dental
… technology. Therefore, theanalysis of pharmaceutical excipients and the evaluation of the characteristics of theformulations were carried out. A preformulation study was carried out to assess thecompatibility of the active pharmaceutical ingredient (API) with the excipients …
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The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets
… continuous tablet forming process of a sample active pharmaceutical ingredient (API) and ethyl acetate requires a device to form and compress the tablets. The flow of the wet extrusion is driven by the pressure head generated by the torque of the screws; the minimum pressure head is dictated by …
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Sample preparation methodologies for MALDI-MS imaging and related topics.
… main themes that have been focussed on are the pharmaceutical and metabolomic applications of this state of the art technique.MALDI MSI has been evaluated as a technique for the detection and imaging of antiasthmatic compounds in lung tissue. Four compounds were assessed initially with …
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QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING
… price. Additionally, aspartame is found in many pharmaceutical drugs to mask the bitter taste of the active pharmaceutical ingredient (API). For instance, lozenges are solid intraoral dosage forms intended to slowly release the API into the oral cavity. Aspartame is used in lozenges to impart a …
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Modeling and Prediction of Amorphous Solid Dispersion Formation Using a Molecular Descriptor
<p>Poor aqueous solubility of an active pharmaceutical ingredient (API) is a significant hurdle during drug development. Delivering a drug in its amorphous solid-state is a potential method to overcome this issue, since the amorphous form has increased apparent aqueous solubility. However, the …
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Development of Sodium Benzoate Tablets with Dual Burst Release: Hydrophilic Matrix System
… burst release system is a method for regulating active pharmaceutical ingredient (API) release in two distinct phases. This type of release system is often preferred over more conventional systems as it enhances efficacy, decreases adverse reactions and reduces dosing frequency. To achieve dual …
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Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
… was separated into four tasks: (1) Formation of pharmaceutical cocrystals: Two pharmaceutical cocrystals of poorly water soluble active pharmaceutical ingredient (API) flufenamic acid (FFA) were synthesized, including 1:1 flufenamic acid-nicotinamide cocrystal (FFA-NIC CO) and 1:1 flufenamic …
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Mechanistic Understanding of Co-crystal solubility and dissolution by using a combination of Experimental and Molecular Modelling Techniques
… separated into four sections: (1) Formation of pharmaceutical co-crystals: Three pharmaceutical co-crystals of poorly water soluble active pharmaceutical ingredient (API) of Flufenamic acid (FFA) and Carbamazepine (CBZ) were synthesized, including 1:1 Flufenamic acid-theophylline co-crystal …
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Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method
<p>Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ultimately its bioavailability. Many of the new therapeutically beneficial compounds discovered are lipophilic requiring various solubility enhancement strategies to improve their solubility. …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… system composed of a polymer excipient and an Active Pharmaceutical Ingredient (API). Indomethacin (INM) is used as model API; Eudragit EPO (EPO) is used as polymer excipient; AcDiSol and Crospovidone (Cros) are used as two kinds of disintegrant. The main objectives are to gain an understanding …
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