Desenvolvimento de antisséptico bucal em pastilha para prevenção da cárie dental

The present research aimed to develop an oral antiseptic lozenge containingcetylpyridinium chloride (CPC), using direct compression technology. Therefore, theanalysis of pharmaceutical excipients and the evaluation of the characteristics of theformulations were carried out. A preformulation study was carried out to assess thecompatibility of the active pharmaceutical ingredient (API) with the excipients usingthermoanalytical techniques: differential scanning calorimetry (DSC), thermogravimetry(TG) and differential thermal analysis (DTA); and mid-infrared (FTIR) and near-infrared(FT-NIR) spectroscopy. The pharmacotechnical characteristics of the mixture of thecomponents in powder form and the physicochemical and organoleptic characteristicsofthe tablets obtained by direct compression were also evaluated. Preliminaryandaccelerated stability studies were carried out under different conditions of storageandpackaging material. The DSC and TG results points to interactions between API andmenthol, with change in the melting point of API. The data obtained by FTIRandFT-NIRdemonstrated a physical interaction proven through statistical analysis of Pearson'scorrelation. A product with adequate pharmacotechnical characteristics in terms of flowand compressibility was obtained, considering the evaluations of characteristics of CarrIndex (CI), Hausner Ratio (RH), particle size distribution, flow velocity, angle of reposeand humidity. The lozenges obtained after direct compression met the characteristics, considering weight, hardness, thickness, friability, disintegration, organolepticcharacteristics and pH value for evaluation. Stability studies showed that the product isstable under the conditions studied when stored in glass or polyethylene terephthalate(PET)bottles. Thus, it can be considered that CPC lozenges with adequate pharmacotechnical characteristics and stability were obtained.

Grantor dc:publisher

Universidade Federal do Rio Grande do Norte

Year dc:date.issued

2022

Author dc:creator

• Aquino, Débora Araújo Othon de

Advisor dc:contributor.advisor

• Ferrari, Márcio

• Antisséptico bucal
• Cloreto de cetilpiridínio
• Pastilha

Statement dc:rights

• Acesso Aberto

Language dc:language

pt_BR

Repository record dc:identifier.uri

https://repositorio.ufrn.br/handle/123456789/49737

OAI identifier oai:identifier

oai:repositorio.ufrn.br:123456789/49737