Estudio de los polimorfismos: rs165932 (intron 8), apoe ε2/3/4 y rs669 (V1000I) y la Enfermedad de Alzheimer de comienzo tardío en la región del noroeste Murciano

[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.

Author

• Rodríguez Manotas, Miguel

• Tesis y disertaciones académicas
• Universidad de Salamanca (España)
• Academic dissertations
• Alzheimer, Enfermedad de
• Alzheimer's disease
• Genética
• Genetics
• Proteínas
• Proteins

Identifier

hdl:10366/76537

OAI identifier oai:identifier

oai:gredos.usal.es:10366/76537