{"id":{"repo_id":"salamanca","oai_identifier":"oai:gredos.usal.es:10366/76537"},"canonical_url":"https://search.dev.ndltd.org/etd/salamanca/oai:gredos.usal.es:10366/76537","repository":{"repo_id":"salamanca","name":"Universidad de Salamanca","base_url":"https://gredos.usal.es/oai/request"},"display":{"title":"Estudio de los polimorfismos: rs165932 (intron 8), apoe ε2/3/4 y rs669 (V1000I) y la Enfermedad de Alzheimer de comienzo tardío en la región del noroeste Murciano","abstract":"[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.","abstract_html":"[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.","abstract_has_math":false,"creators":["Rodríguez Manotas, Miguel"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-10","date_published":"2009-10","updated_at":"2026-07-27T20:53:56Z","subjects":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Alzheimer, Enfermedad de","Alzheimer's disease","Genética","Genetics","Proteínas","Proteins"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/76537"],"render_values":[{"text":"hdl:10366/76537","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.14201/gredos.76537","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2009-10"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Alzheimer, Enfermedad de","Alzheimer's disease","Genética","Genetics","Proteínas","Proteins"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10366/76537"]},{"key":"dc:identifier.doi","label":"DOI","values":["10.14201/gredos.76537"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.","[ES] Los objetos de esta tesis son: 1. Desarrollar un método automatizado para facilitar la búsqueda de una asociación entre la enfermedad de Alzheimer de comienzo tardío (LOAD) y el polimorfismo intrónico del extremo 3’ del exón 8 del gen de la Presenilina 1 (SNP cluster report rs165932). 2. Realizar un estudio basado en casos clínicos para determinar la prevalencia del polimorfismo intrónico de PS-1 y su relación con los polimorfismos de la ApoE respecto a LOAD en un área rural del sureste de España, cuya población ha permanecido relativamente estable. Este estudio sería complementado con un metanálisis centrado en el genotipo PS-1 [2/2] del citado polimorfismo. 3. Llevar a cabo un estudio del polimorfismo V1000I (SNP cluster report rs669) en el gen de la α-2-Macroglobulina y la susceptibilidad de padecer LOAD."]},{"key":"dc:title","label":"Title","values":["Estudio de los polimorfismos: rs165932 (intron 8), apoe ε2/3/4 y rs669 (V1000I) y la Enfermedad de Alzheimer de comienzo tardío en la región del noroeste Murciano"]}]}],"canonical_facts":{"dc:date.issued":["2009-10"],"dc:description.other":["[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.","[ES] Los objetos de esta tesis son: 1. Desarrollar un método automatizado para facilitar la búsqueda de una asociación entre la enfermedad de Alzheimer de comienzo tardío (LOAD) y el polimorfismo intrónico del extremo 3’ del exón 8 del gen de la Presenilina 1 (SNP cluster report rs165932). 2. Realizar un estudio basado en casos clínicos para determinar la prevalencia del polimorfismo intrónico de PS-1 y su relación con los polimorfismos de la ApoE respecto a LOAD en un área rural del sureste de España, cuya población ha permanecido relativamente estable. Este estudio sería complementado con un metanálisis centrado en el genotipo PS-1 [2/2] del citado polimorfismo. 3. Llevar a cabo un estudio del polimorfismo V1000I (SNP cluster report rs669) en el gen de la α-2-Macroglobulina y la susceptibilidad de padecer LOAD."],"dc:identifier":["hdl:10366/76537"],"dc:identifier.doi":["10.14201/gredos.76537"],"dc:subject":["Tesis y disertaciones académicas","Universidad de Salamanca (España)","Academic dissertations","Alzheimer, Enfermedad de","Alzheimer's disease","Genética","Genetics","Proteínas","Proteins"],"dc:title":["Estudio de los polimorfismos: rs165932 (intron 8), apoe ε2/3/4 y rs669 (V1000I) y la Enfermedad de Alzheimer de comienzo tardío en la región del noroeste Murciano"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-27T20:53:56Z"}