Estudio de los polimorfismos: rs165932 (intron 8), apoe ε2/3/4 y rs669 (V1000I) y la Enfermedad de Alzheimer de comienzo tardío en la región del noroeste Murciano
[EN] The objects of this thesis are: 1. Develop an automated method to facilitate the search for an association between Alzheimer's disease late onset (LOAD) and the intronic polymorphism of the 3 'end of exon 8 of presenilin 1 gene (SNP rs165932 cluster report). 2. Conduct a study based on clinical cases to determine the prevalence of intronic polymorphism of PS-1 and its relation to the ApoE polymorphism with respect to LOAD in a rural area of southeast Spain, whose population has remained relatively stable. This study would be complemented a meta-analysis focused on the PS-1 genotype [2 / 2] of that polymorphism. 3. Conduct a study V1000I polymorphism (SNP cluster report rs669) in the gene for α-2-Macroglobulin and the susceptibility of developing LOAD.
Tesis y disertaciones académicas, Universidad de Salamanca (España), Academic dissertations, Alzheimer, Enfermedad de, Alzheimer's disease, Genética, Genetics, Proteínas, Proteins
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