SYNTHETIC STUDIES ON THE SAFRAMYCINS A, B AND S: A TOTAL SYNTHESIS OF SAFRAMYCIN B

The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The first and only synthesis of saframycin B is described herein. The interesting aspects of this synthesis are the convergent approach and the method of stereochemical control. Studies directed towards adapting the saframycin B synthesis to the synthesis of saframycins A and S are also described. These studies have resulted in the synthesis of a compound structurally related to the saframycins but so far unreported in the literature. (DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Natural Sciences

Grantor

Rice University

Year dc:date.issued

1985

Author dc:creator

• SACHLEBEN, RICHARD ALAN

• Organic chemistry

Statement dc:rights

• Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1911/15930

OAI identifier oai:identifier

oai:repository.rice.edu:1911/15930