{"id":{"repo_id":"rice","oai_identifier":"oai:repository.rice.edu:1911/15930"},"canonical_url":"https://search.dev.ndltd.org/etd/rice/oai:repository.rice.edu:1911/15930","repository":{"repo_id":"rice","name":"Rice University","base_url":"https://repository.rice.edu/server/oai/request"},"display":{"title":"SYNTHETIC STUDIES ON THE SAFRAMYCINS A, B AND S: A TOTAL SYNTHESIS OF SAFRAMYCIN B","abstract":"The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The first and only synthesis of saframycin B is described herein. The interesting aspects of this synthesis are the convergent approach and the method of stereochemical control. Studies directed towards adapting the saframycin B synthesis to the synthesis of saframycins A and S are also described. These studies have resulted in the synthesis of a compound structurally related to the saframycins but so far unreported in the literature. (DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)","abstract_html":"The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The first and only synthesis of saframycin B is described herein. The interesting aspects of this synthesis are the convergent approach and the method of stereochemical control. Studies directed towards adapting the saframycin B synthesis to the synthesis of saframycins A and S are also described. These studies have resulted in the synthesis of a compound structurally related to the saframycins but so far unreported in the literature. (DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)","abstract_has_math":false,"creators":["SACHLEBEN, RICHARD ALAN"],"institution":"Rice University","degree_name":"Doctor of Philosophy","degree_level":"Doctoral","degree_discipline":"Natural Sciences","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1985,"date_issued":"1985","date_published":"1985","updated_at":"2026-07-24T04:10:21Z","subjects":["Organic chemistry"],"languages":["eng"],"rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1911/15930","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["SACHLEBEN, RICHARD ALAN"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2007-05-09T19:39:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2007-05-09T19:39:41Z"]},{"key":"dc:date.issued","label":"Date","values":["1985"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Natural Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Rice University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organic chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the author, unless otherwise indicated. 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(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["SYNTHETIC STUDIES ON THE SAFRAMYCINS A, B AND S: A TOTAL SYNTHESIS OF SAFRAMYCIN B"]}]}],"canonical_facts":{"dc:creator":["SACHLEBEN, RICHARD ALAN"],"dc:date.accessioned":["2007-05-09T19:39:41Z"],"dc:date.available":["2007-05-09T19:39:41Z"],"dc:date.issued":["1985"],"dc:description.abstract":["The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The first and only synthesis of saframycin B is described herein. The interesting aspects of this synthesis are the convergent approach and the method of stereochemical control. Studies directed towards adapting the saframycin B synthesis to the synthesis of saframycins A and S are also described. These studies have resulted in the synthesis of a compound structurally related to the saframycins but so far unreported in the literature. (DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)"],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/1911/15930"],"dc:language.iso":["eng"],"dc:rights":["Copyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder."],"dc:subject":["Organic chemistry"],"dc:title":["SYNTHETIC STUDIES ON THE SAFRAMYCINS A, B AND S: A TOTAL SYNTHESIS OF SAFRAMYCIN B"],"dc:type":["Thesis"],"thesis:degree_discipline":["Natural Sciences"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Doctor of Philosophy"],"thesis:institution_name":["Rice University"]},"updated_at":"2026-07-24T04:10:21Z"}