ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΥΠΟΠΛΗΘΥΣΜΩΝ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ

PERNICIOUS ANEMIA IS A DISEASE CHARACTERISED BY MANY AUTOIMMUNE FEATURES. IN THIS STUDY I INVESTIGATED THE LYMPHOCYTE SUBPOPULATIONS IN THE BLOOD OF PATIENTS WITH MEGALOBLASTIC ANEMIA AND THE IN VITRO EFFECT OF STEROIDS ON T-LYMPHOCYTES OF THESE PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH PERNICIOUS ANEMIA WAS SIGNIFICANTLY INCREASED . THIS WAS DUE MAINLY TO A DEFICIENCY OF CIRCULATING SUPPRESSOR T-CELLS AND SECONDARILY TO AN INCREASE OF HELPER T-CELLS. VITAMIN BIZ THERAPY CAN NOT RESTORE THE ABNORMAL H/S RATIO. I ALSO FOUND A SLIGHT, NOT SIGNIFICANT, OF NATURAL KILLER (NK) CELLS, IN PATIENTS WITH PERNICIOUS ANEMIA. FINALLY, I OBSERVED THAT STEROIDS REDUCE IN A GREATED SCALE THE MITOGENIC EFFECT OF PHYTOHEMOAGGLUTININE (PHA) ON HELPER T-LYMPHOCYTES OF PATIENTS WITH PERNICIOUS ANEMIA, THAN IN NORMAL CONTROLS.

Grantor dc:publisher

University of Patras

Year dc:date

1987

Authors dc:creator

• Gogos, Charalambos
• Γώγος, Χαράλαμπος

• Κακοήθης αναιμία
• ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ
• Μονοκλωνικά αντισώματα
• Κατονομαστική αφασία
• Φυσικά κυτταροκτόνα κύτταρα (ΝΚ)
• MEGALOBLASTIC ANEMIA
• Monoclonal antibodies
• Natural killer cells
• PERNICIOUS ANEMIA
• T-lymphocytes subsets
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0662

OAI identifier oai:identifier

oai:10442/0662