ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΥΠΟΠΛΗΘΥΣΜΩΝ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ
type: CreativeWork
description: PERNICIOUS ANEMIA IS A DISEASE CHARACTERISED BY MANY AUTOIMMUNE FEATURES. IN THIS STUDY I INVESTIGATED THE LYMPHOCYTE SUBPOPULATIONS IN THE BLOOD OF PATIENTS WITH MEGALOBLASTIC ANEMIA AND THE IN VITRO EFFECT OF STEROIDS ON T-LYMPHOCYTES OF THESE PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH PERNICIOUS ANEMIA WAS SIGNIFICANTLY INCREASED . THIS WAS DUE MAINLY TO A DEFICIENCY OF CIRCULATING SUPPRESSOR T-CELLS AND SECONDARILY TO AN INCREASE OF HELPER T-CELLS. VITAMIN BIZ THERAPY CAN NOT RESTORE THE ABNORMAL H/S RATIO. I ALSO FOUND A SLIGHT, NOT SIGNIFICANT, OF NATURAL KILLER (NK) CELLS, IN PATIENTS WITH PERNICIOUS ANEMIA. FINALLY, I OBSERVED THAT STEROIDS REDUCE IN A GREATED SCALE THE MITOGENIC EFFECT OF PHYTOHEMOAGGLUTININE (PHA) ON HELPER T-LYMPHOCYTES OF PATIENTS WITH PERNICIOUS ANEMIA, THAN IN NORMAL CONTROLS.
abstract: PERNICIOUS ANEMIA IS A DISEASE CHARACTERISED BY MANY AUTOIMMUNE FEATURES. IN THIS STUDY I INVESTIGATED THE LYMPHOCYTE SUBPOPULATIONS IN THE BLOOD OF PATIENTS WITH MEGALOBLASTIC ANEMIA AND THE IN VITRO EFFECT OF STEROIDS ON T-LYMPHOCYTES OF THESE PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH PERNICIOUS ANEMIA WAS SIGNIFICANTLY INCREASED . THIS WAS DUE MAINLY TO A DEFICIENCY OF CIRCULATING SUPPRESSOR T-CELLS AND SECONDARILY TO AN INCREASE OF HELPER T-CELLS. VITAMIN BIZ THERAPY CAN NOT RESTORE THE ABNORMAL H/S RATIO. I ALSO FOUND A SLIGHT, NOT SIGNIFICANT, OF NATURAL KILLER (NK) CELLS, IN PATIENTS WITH PERNICIOUS ANEMIA. FINALLY, I OBSERVED THAT STEROIDS REDUCE IN A GREATED SCALE THE MITOGENIC EFFECT OF PHYTOHEMOAGGLUTININE (PHA) ON HELPER T-LYMPHOCYTES OF PATIENTS WITH PERNICIOUS ANEMIA, THAN IN NORMAL CONTROLS.
author: Gogos, Charalambos
author: Γώγος, Χαράλαμπος
language: gre
keywords: Κακοήθης αναιμία, ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ, Μονοκλωνικά αντισώματα, Κατονομαστική αφασία, Φυσικά κυτταροκτόνα κύτταρα (ΝΚ), MEGALOBLASTIC ANEMIA, Monoclonal antibodies, Natural killer cells, PERNICIOUS ANEMIA, T-lymphocytes subsets, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
date published: 1987
date modified: 2026-07-24T02:25:24Z
provider: Greek National Archive of PhD Theses
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Patras

PropertyValue
property ID: DOI
value: 10.12681/eadd/0662

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10442/hedi/0662