ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΥΠΟΠΛΗΘΥΣΜΩΝ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ
PERNICIOUS ANEMIA IS A DISEASE CHARACTERISED BY MANY AUTOIMMUNE FEATURES. IN THIS STUDY I INVESTIGATED THE LYMPHOCYTE SUBPOPULATIONS IN THE BLOOD OF PATIENTS WITH MEGALOBLASTIC ANEMIA AND THE IN VITRO EFFECT OF STEROIDS ON T-LYMPHOCYTES OF THESE PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH PERNICIOUS ANEMIA WAS SIGNIFICANTLY INCREASED . THIS WAS DUE MAINLY TO A DEFICIENCY OF CIRCULATING SUPPRESSOR T-CELLS AND SECONDARILY TO AN INCREASE OF HELPER T-CELLS. VITAMIN BIZ THERAPY CAN NOT RESTORE THE ABNORMAL H/S RATIO. I ALSO FOUND A SLIGHT, NOT SIGNIFICANT, OF NATURAL KILLER (NK) CELLS, IN PATIENTS WITH PERNICIOUS ANEMIA. FINALLY, I OBSERVED THAT STEROIDS REDUCE IN A GREATED SCALE THE MITOGENIC EFFECT OF PHYTOHEMOAGGLUTININE (PHA) ON HELPER T-LYMPHOCYTES OF PATIENTS WITH PERNICIOUS ANEMIA, THAN IN NORMAL CONTROLS.
Κακοήθης αναιμία, ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ, Μονοκλωνικά αντισώματα, Κατονομαστική αφασία, Φυσικά κυτταροκτόνα κύτταρα (ΝΚ), MEGALOBLASTIC ANEMIA, Monoclonal antibodies, Natural killer cells, PERNICIOUS ANEMIA, T-lymphocytes subsets, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
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