The Association Between Pro-Inflammatory Cytokines and C-Reactive-Protein and the Cognitive and Neurological Outcome in Stroke Survivors: A Systematic Review

The role of inflammation in neurological prognosis of stroke has been studied previously. However, very little research has thoroughly examined the association between inflammatory markers and neurocognitive outcome post-stroke. Our main goal was to examine the existing literature and this association between inflammatory markers and post-stroke functioning, primarily by examining the tools and methods chosen by researchers to assess neurocognitive outcomes. A systematic literature search retrieved 954 articles to review against inclusion criteria. A total of 21 articles were included in this review. Across the studies, we identified two common themes: 1) lack of research into the diverse stroke populations; and 2) lack of comprehensive neurocognitive measures. Our findings show that research on the area of inflammation and neurocognitive outcome post-stroke has been inconsistent in terms of the methods used, and our conclusions will direct future research exploring the role of inflammatory markers in prediction of cognitive functioning post-stroke.

Author dc:creator

• Kahnami, Leila

Advisor dc:contributor.advisor

• Desrocher, Mary E.

• Developmental psychology

Statement dc:rights

• Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.

Language dc:language

en

Handle dc:identifier.uri

http://hdl.handle.net/10315/38708

OAI identifier oai:identifier

oai:yorkspace.library.yorku.ca:10315/38708