Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis

Inhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS.

Author dc:creator

• Lysenko, Magdalena

Advisor dc:contributor.advisor

• Till, Christine

• Developmental psychology
• Cognitive psychology
• Medical imaging and radiology

Statement dc:rights

• Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10315/27696

OAI identifier oai:identifier

oai:yorkspace.library.yorku.ca:10315/27696