{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/27696"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/27696","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis","abstract":"Inhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS.","abstract_html":"Inhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS.","abstract_has_math":false,"creators":["Lysenko, Magdalena"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Till, Christine"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-07-28","date_published":"2014-07-28","updated_at":"2026-07-24T06:33:51Z","subjects":["Developmental psychology","Cognitive psychology","Medical imaging and radiology"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10315/27696","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Till, Christine"]},{"key":"dc:creator","label":"Author","values":["Lysenko, Magdalena"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-31T15:49:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-31T15:49:15Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-07-28"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Developmental psychology","Cognitive psychology","Medical imaging and radiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10315/27696"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Inhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS."]},{"key":"dc:title","label":"Title","values":["Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis"]}]}],"canonical_facts":{"dc:contributor.advisor":["Till, Christine"],"dc:creator":["Lysenko, Magdalena"],"dc:date.accessioned":["2014-07-31T15:49:15Z"],"dc:date.available":["2014-07-31T15:49:15Z"],"dc:date.issued":["2014-07-28"],"dc:description.abstract":["Inhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS."],"dc:identifier.uri":["http://hdl.handle.net/10315/27696"],"dc:language.iso":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Developmental psychology","Cognitive psychology","Medical imaging and radiology"],"dc:title":["Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:51Z"}