Cardiotoxicity In Hematologic Stem Cell Transplant: Keeping The Beat

<p>Abstract</p> <p>The number of hematopoietic stem cell transplants (HSCT) performed in the U.S. and worldwide is increasing. Cardiac events have been well described in HSCT, and incidence and type of cardiac events have not changed over recent decades. This study adds to the body of evidence in describing incidence and type of cardiac events experienced by an allogeneic and autologous HSCT population at one institution from 2012-2017. Sixty-five patients (9.8%) experienced cardiac events, including atrial arrhythmia (N = 39), acute heart failure (N = 9), acute coronary syndrome (N = 7), new onset hypertension (N = 9), with a few instances of bradycardia, ventricular arrhythmia, pericardial effusion, and pericarditis. Our multivariable regression analysis identified age (older), creatinine (higher) and history of coronary artery disease to significantly correlate with risk of cardiac event (p = 0.005, p = 0.039, p = 0.038 respectively). Patients developing a CE had an increased risk of death within one year (11% vs. 32%, p</p>

Name thesis:degree_name

Doctor of Nursing Practice (DNP)

Level thesis:degree_level

Open Access Thesis

Discipline thesis:degree_discipline

Yale University School of Nursing

Year

2019

Author dc:creator

• Baker, Julie K

Contributors dc:contributor

• Jessica Coviello

• Cardiotoxicity
• Hematopoietic stem cell transplant
• Risk assessment

Repository record dc:identifier

https://elischolar.library.yale.edu/ysndt/1083

OAI identifier oai:identifier

oai:elischolar.library.yale.edu:ysndt-1082