Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"cardiotoxicity"”.
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The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
… and safe antagonist of Doxorubicin-induced cardiotoxicity remains a challenge. In recent years, researchers have investigated the use of plant-derived polyphenols as nutraceuticals to lower the risk of chronic diseases. Of particular interest is aspalathin, a plant polyphenol with known …
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Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity
The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of …
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Cardiotoxicity In Hematologic Stem Cell Transplant: Keeping The Beat
<p>Abstract</p> <p>The number of hematopoietic stem cell transplants (HSCT) performed in the U.S. and worldwide is increasing. Cardiac events have been well described in HSCT, and incidence and type of cardiac events have not changed over recent decades. This study adds to the body of evidence in …
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Dysregulation of connexin-43 (cx43) in doxorubicin-induced cardiotoxicity
… however patients experience dose-dependent cardiotoxicity that can manifest acute, early- and late-onset chronic and is associated with a decreased contractility and dilated cardiomyopathy. Similar effects have been reported during cardiac malfunction, which have been linked with a …
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Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
… with debilitating side effects, including cardiotoxicity. Ethanolamine has previously been shown to protect the isolated heart against ischaemia-reperfusion injury, however, its use as a cardioprotective agent against doxorubicin-induced cardiotoxicity has not been assessed. Therefore, in …
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The genetics of anthracycline-induced cardiotoxicity in cancer patients
… by the increased risk of anthracycline-induced cardiotoxicity (ACT) - estimated at 10-26%. Internationally, there has been evidence of ACT having a genetic basis. Currently in South Africa, there is little information on ACT in cancer patients and survivors, and no information on the genetic …
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Artificial Intelligence (AI)-assisted Cardiotoxicity Management in Lung Cancer Radiotherapy
… of treatment. However, radiation-induced cardiotoxicity has emerged as a significant long-term complication, impacting patient survival and quality of life. There is increasing evidence that post-radiotherapy cardiotoxicity is better indicated by cardiac substructure dose, compared with …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis following injection (14.2 ± 1.1% for doxorubicin-5 d vs. …
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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
… myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection fraction (LVEF). As cancer survival rates increase, the occurrence of chemotherapy induced …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
… to identify the mechanism of sunitinib-induced cardiotoxicity in order to develop strategies to prevent clinical cardiotoxicity and, secondly, to use this mechanistic insight as a discovery platform to identify new targets for the treatment of human heart failure. My work led to the discovery …
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Doxorubicin-Induced Cardiotoxicity Is Mediated By Neutrophils Through Release of Neutrophil Elastase
… mechanisms by which Dox causes acute and late cardiotoxicity are not completely understood. One understudied area in Dox-induced cardiotoxicity is the contribution of inflammation and innate immune cells, in particular neutrophils. Recognizing that neutrophils have been implicated in a number …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
… first-line treatment for cancers, it can induce cardiotoxicity which is associated with increased production of myocardial reactive oxygen species (ROS). Recent work has suggested that ROS generated specifically from Nox2 NADPH oxidase, contributes to key processes underlying cardiac dysfunction …
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The protective effect of α-lipoic acid in doxorubicin induced cardiotoxicity in rats.
… in protecting rats from doxorubicin induced cardiotoxicity.
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Prevention of cancer therapy related cardiotoxicity: A Tayside Pharmaco-Epidemiology study (PROTECT-TAYSIDE study)
… used in breast cancer and may cause irreversible cardiotoxicity, though trastuzumab-induced damage can be reversed upon stopping. Various animal studies have shown that cardioprotective drugs such as ACE inhibitors, Beta-blockers and statins can reduce pathological processes such as oxidative …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… is cardioprotective against drug-induced cardiotoxicity and apoptosis via modifying diverse heart failure-related signalling pathways. This provides novel insight on the possible use of melatonin as an adjunct intervention in several therapies including anti-cancer.
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Survival after local anaesthetic overdose : a comparison of the success of resuscitation after established cardiotoxicity caused by ropivacaine or bupivacaine
… whether ropivacaine is a safer drug, once cardiotoxicity has occurred.
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Doxorubicin Inhibits Cardiomyocyte Autophagic Flux by Suppressing Lysosomal Acidification
The clinical use of doxorubicin is limited by cardiotoxicity. Dysregulation of autophagy in the myocardium has been implicated in a variety of cardiovascular diseases. However, the role of autophagy in doxorubicin cardiomyopathy remains poorly defined. Most models of acute doxorubicin …
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Exploring the relationship between shifts in high-density lipoprotein (HDL) particle subclass distribution/functionality and cardiac function in doxorubicin (DOX)-induced cardiotoxicity
… Elucidating the mechanisms involved in cardiotoxicity that develops in cancer patients receiving doxorubicin (DOX) chemotherapy is key to identify potential cardioprotective strategies and early biomarkers in these patients. Both breast cancer and DOX treatment are associated with …
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