Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application

Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca²⁺ versus voltage dependent inactivation of L-type Ca²⁺ current; kinetics for the transient outward, rapid delayed rectifier, Na⁺/Ca²⁺ exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the "silent" Long-QT mutation Q357R in KCNQ1.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biomedical Engineering

Year dc:date.available

2011

Author dc:creator

• O'Hara, Thomas

Contributors dc:contributor

• Yoram Rudy

• Biomedical Engineering

Language dc:language

English (en)

DOI

https://doi.org/10.7936/K70R9MCM

OAI identifier oai:identifier

oai:openscholarship.wustl.edu:etd-1872