{"id":{"repo_id":"wustl","oai_identifier":"oai:openscholarship.wustl.edu:etd-1872"},"canonical_url":"https://search.dev.ndltd.org/etd/wustl/oai:openscholarship.wustl.edu:etd-1872","repository":{"repo_id":"wustl","name":"Washington University in St. Louis","base_url":"https://openscholarship.wustl.edu/do/oai/"},"display":{"title":"Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application","abstract":"Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca<sup>2+</sup> versus voltage dependent inactivation of L-type Ca<sup>2+</sup> current; kinetics for the transient outward, rapid delayed rectifier, Na<sup>+</sup>/Ca<sup>2+</sup> exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the \"silent\" Long-QT mutation Q357R in KCNQ1.","abstract_html":"Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca&lt;sup&gt;2+&lt;/sup&gt; versus voltage dependent inactivation of L-type Ca&lt;sup&gt;2+&lt;/sup&gt; current; kinetics for the transient outward, rapid delayed rectifier, Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt; exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the &quot;silent&quot; Long-QT mutation Q357R in KCNQ1.","abstract_has_math":false,"creators":["O'Hara, Thomas"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Yoram Rudy"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-24T07:00:00Z","date_published":"2011-05-24T07:00:00Z","updated_at":"2026-07-24T06:12:48Z","subjects":["Biomedical Engineering"],"languages":["English (en)"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7936/K70R9MCM"],"render_values":[{"text":"https://doi.org/10.7936/K70R9MCM","href":"https://doi.org/10.7936/K70R9MCM","code":true}]}]},"links":{"outbound_url":"https://openscholarship.wustl.edu/etd/873","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Yoram Rudy"]},{"key":"dc:creator","label":"Author","values":["O'Hara, Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2013-05-25T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomedical Engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English (en)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://openscholarship.wustl.edu/etd/873"]},{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7936/K70R9MCM"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca<sup>2+</sup> versus voltage dependent inactivation of L-type Ca<sup>2+</sup> current; kinetics for the transient outward, rapid delayed rectifier, Na<sup>+</sup>/Ca<sup>2+</sup> exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the \"silent\" Long-QT mutation Q357R in KCNQ1."]},{"key":"dc:title","label":"Title","values":["Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application"]}]}],"canonical_facts":{"dc:contributor":["Yoram Rudy"],"dc:creator":["O'Hara, Thomas"],"dc:date.available":["2013-05-25T07:00:00Z"],"dc:description.abstract":["Creation of an accurate model for the undiseased human ventricular action potential: AP) which reproduces a broad range of physiological behaviors requires extensive experimental data, of which essential elements have been unavailable. We developed and validated such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca<sup>2+</sup> versus voltage dependent inactivation of L-type Ca<sup>2+</sup> current; kinetics for the transient outward, rapid delayed rectifier, Na<sup>+</sup>/Ca<sup>2+</sup> exchange, and inward rectifier currents; AP recordings at all physiological cycle lengths; steady state rate dependence and restitution of AP duration. The model was used to investigate the \"silent\" Long-QT mutation Q357R in KCNQ1."],"dc:identifier":["https://openscholarship.wustl.edu/etd/873"],"dc:identifier.doi":["https://doi.org/10.7936/K70R9MCM"],"dc:language":["English (en)"],"dc:subject":["Biomedical Engineering"],"dc:title":["Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T06:12:48Z"}