Washington University in St. Louis
Magnetic Resonance Elastography of the Brain: from Phantom to Mouse to Man
Abstract
dc:description.abstractThe overall objective of this study is to develop magnetic resonance elastography: MRE) imaging to better understand brain deformation, brain tissue mechanical properties, and brain-skull interaction in vivo. The findings of this study provide parameters for numerical models of human head biomechanics, as well as data for validation of these models. Numerical simulations offer enormous potential to the study of traumatic brain injury: TBI) and may also contribute to the development of prophylactic devices for high-risk subjects: e.g., military personnel, first-responders, and athletes). Current numerical models have not been adequately parameterized or validated and their predictions remain controversial. This dissertation describes three kinds of MRE experiments, conducted in phantom: physical model), mouse, and man. Phantom studies provide a means to experimentally confirm the accuracy of MRE estimates of viscoelastic parameters in relatively simple materials and geometries. Studies in the mouse provide insight into the dispersive nature of brain tissue mechanical properties at frequencies beyond those that can be measured in humans. Studies in human subjects provide direct measurements of the human brain's response to dynamic extracranial loads, including skull-brain energy transmission and viscoelastic properties.
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Mechanical Engineering and Materials Science
- Year dc:date.available
- 2012
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Clayton, Erik
- Contributors dc:contributor
-
- Philip Bayly
Subjects
dc:subject × 9Rights
- Language dc:language
- English (en)
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:openscholarship.wustl.edu:etd-1683