{"id":{"repo_id":"wustl","oai_identifier":"oai:openscholarship.wustl.edu:etd-1683"},"canonical_url":"https://search.dev.ndltd.org/etd/wustl/oai:openscholarship.wustl.edu:etd-1683","repository":{"repo_id":"wustl","name":"Washington University in St. Louis","base_url":"https://openscholarship.wustl.edu/do/oai/"},"display":{"title":"Magnetic Resonance Elastography of the Brain: from Phantom to Mouse to Man","abstract":"The overall objective of this study is to develop magnetic resonance elastography: MRE) imaging to better understand brain deformation, brain tissue mechanical properties, and brain-skull interaction in vivo. The findings of this study provide parameters for numerical models of human head biomechanics, as well as data for validation of these models. Numerical simulations offer enormous potential to the study of traumatic brain injury: TBI) and may also contribute to the development of prophylactic devices for high-risk subjects: e.g., military personnel, first-responders, and athletes). Current numerical models have not been adequately parameterized or validated and their predictions remain controversial. This dissertation describes three kinds of MRE experiments, conducted in phantom: physical model), mouse, and man. Phantom studies provide a means to experimentally confirm the accuracy of MRE estimates of viscoelastic parameters in relatively simple materials and geometries. Studies in the mouse provide insight into the dispersive nature of brain tissue mechanical properties at frequencies beyond those that can be measured in humans. Studies in human subjects provide direct measurements of the human brain's response to dynamic extracranial loads, including skull-brain energy transmission and viscoelastic properties.","abstract_html":"The overall objective of this study is to develop magnetic resonance elastography: MRE) imaging to better understand brain deformation, brain tissue mechanical properties, and brain-skull interaction in vivo. The findings of this study provide parameters for numerical models of human head biomechanics, as well as data for validation of these models. Numerical simulations offer enormous potential to the study of traumatic brain injury: TBI) and may also contribute to the development of prophylactic devices for high-risk subjects: e.g., military personnel, first-responders, and athletes). Current numerical models have not been adequately parameterized or validated and their predictions remain controversial. This dissertation describes three kinds of MRE experiments, conducted in phantom: physical model), mouse, and man. Phantom studies provide a means to experimentally confirm the accuracy of MRE estimates of viscoelastic parameters in relatively simple materials and geometries. Studies in the mouse provide insight into the dispersive nature of brain tissue mechanical properties at frequencies beyond those that can be measured in humans. Studies in human subjects provide direct measurements of the human brain's response to dynamic extracranial loads, including skull-brain energy transmission and viscoelastic properties.","abstract_has_math":false,"creators":["Clayton, Erik"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Mechanical Engineering and Materials Science","degree_department":null,"school":null,"contributors":["Philip Bayly"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-05-24T07:00:00Z","date_published":"2012-05-24T07:00:00Z","updated_at":"2026-07-24T06:13:05Z","subjects":["Biomechanics","Biomedical engineering","Mechanical engineering","Deformation","Human","Magnetic Resonance Imaging: MRE)","Magnetic Resonance Imaging: MRI)","Mechanical Material Properties","Traumatic Brain Injury: TBI)"],"languages":["English (en)"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7936/K79K489R"],"render_values":[{"text":"https://doi.org/10.7936/K79K489R","href":"https://doi.org/10.7936/K79K489R","code":true}]}]},"links":{"outbound_url":"https://openscholarship.wustl.edu/etd/684","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Philip Bayly"]},{"key":"dc:creator","label":"Author","values":["Clayton, Erik"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2013-02-22T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering and Materials Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomechanics","Biomedical engineering","Mechanical engineering","Deformation","Human","Magnetic Resonance Imaging: MRE)","Magnetic Resonance Imaging: MRI)","Mechanical Material Properties","Traumatic Brain Injury: TBI)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English (en)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://openscholarship.wustl.edu/etd/684"]},{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.7936/K79K489R"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The overall objective of this study is to develop magnetic resonance elastography: MRE) imaging to better understand brain deformation, brain tissue mechanical properties, and brain-skull interaction in vivo. The findings of this study provide parameters for numerical models of human head biomechanics, as well as data for validation of these models. Numerical simulations offer enormous potential to the study of traumatic brain injury: TBI) and may also contribute to the development of prophylactic devices for high-risk subjects: e.g., military personnel, first-responders, and athletes). Current numerical models have not been adequately parameterized or validated and their predictions remain controversial. This dissertation describes three kinds of MRE experiments, conducted in phantom: physical model), mouse, and man. Phantom studies provide a means to experimentally confirm the accuracy of MRE estimates of viscoelastic parameters in relatively simple materials and geometries. Studies in the mouse provide insight into the dispersive nature of brain tissue mechanical properties at frequencies beyond those that can be measured in humans. Studies in human subjects provide direct measurements of the human brain's response to dynamic extracranial loads, including skull-brain energy transmission and viscoelastic properties."]},{"key":"dc:title","label":"Title","values":["Magnetic Resonance Elastography of the Brain: from Phantom to Mouse to Man"]}]}],"canonical_facts":{"dc:contributor":["Philip Bayly"],"dc:creator":["Clayton, Erik"],"dc:date.available":["2013-02-22T08:00:00Z"],"dc:description.abstract":["The overall objective of this study is to develop magnetic resonance elastography: MRE) imaging to better understand brain deformation, brain tissue mechanical properties, and brain-skull interaction in vivo. The findings of this study provide parameters for numerical models of human head biomechanics, as well as data for validation of these models. Numerical simulations offer enormous potential to the study of traumatic brain injury: TBI) and may also contribute to the development of prophylactic devices for high-risk subjects: e.g., military personnel, first-responders, and athletes). Current numerical models have not been adequately parameterized or validated and their predictions remain controversial. This dissertation describes three kinds of MRE experiments, conducted in phantom: physical model), mouse, and man. Phantom studies provide a means to experimentally confirm the accuracy of MRE estimates of viscoelastic parameters in relatively simple materials and geometries. Studies in the mouse provide insight into the dispersive nature of brain tissue mechanical properties at frequencies beyond those that can be measured in humans. 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