Development of Radiochemical Quality Control Methods for Ra-223 and Th-227 Radiotherapies

<p><strong>Introduction.</strong> Radiolabeled molecules for use in disease detection and targeted treatment are a mainstay of patient management. The majority of radiopharmaceuticals deployed to date undergo a single radioactive transition (decay) to reach a stable ground state. Complex emitters, which produce a series of daughter radionuclides, are emerging as novel radiopharmaceuticals, and there is a need for the proper validation of content and purity using common quality control instrumentation. <strong>Hypothesis.</strong> There is a need for proper characterization of complex emitters for more accurate quality control on readily available equipment. Here, we demonstrate the novel characterization of Th-227 and Ra-223 using a solid-state semiconductor alpha detector, a gamma counter, and a radio-TLC scanner, three widely accessible technologies. <strong>Results.</strong> In this work, we validate the ability of the alpha particle spectral imaging camera and the gamma counter to distinguish Th-227 from Ra-223, allowing for fast, qualitative, and quantitative determination of radionucleic purity. We also assess the utility and accuracy of the Bioscan radio-TLC to measure these radionuclides under different high voltage settings. Finally, we validate our results and demonstrate the practical applications of this work through evaluation of a Th-227-labeled antibody construct. <strong>Conclusion.</strong> Our results develop a novel quality control protocol for Th-227 and Ra-223 on three different, readily available instruments. These results can be applied to both research and clinical settings as new alpha particle therapies are developed for cancer treatment.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biomedical Engineering

Year dc:date.available

2021

Author dc:creator

• Hasson, Abigail

Contributors dc:contributor

• Daniel Thorek
• Diane Abou Michael Nickles

• Radiochemistry
• Thorium
• Radium
• Quality Control
• Radioisotope
• Radio labeled Antibody
• Engineering

Statement dc:rights

• I have not registered my thesis with the U.S. Copyright Office, but intend to later.

Language dc:language

English (en)

Identifier

https://openscholarship.wustl.edu/eng_etds/674

OAI identifier oai:identifier

oai:openscholarship.wustl.edu:eng_etds-1742