Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Radiochemistry"”.
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Development of 18F radiochemistry for positron emission particle tracking (PEPT)
Positron emission particle tracking (PEPT) is a non-invasive tracer-based measurement technique used to obtain dynamic information about multiphase systems. The basis of the technique is to radiolabel a phase-representative tracer particle with a positron emitting radionuclide. Electron-positron …
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Alpha-radioactive isotopes in the marine environment.
… waters around Cape Town were analysed by radiochemistry and alpha-spectrometry for Pu-239, 240. Many of these organisms were also analysed for Pu-238, Po-210 and - those isotopes of thorium and uranium that are alpha-emitters. In some samples an estimate of the Ra-226 content was also …
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I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18
… are in highly demand in the field of radiochemistry. Chapter 1 presents an introduction of PET imaging techniques, and outlines the basics of F-18 radiochemistry, which focuses on the synthetic difficulties associated with the nature of fluoride and especially F-18. It also highlights …
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Comparative Analysis of Source Term Removal at Cook Nuclear Plant
… for future analysis to better understand the radiochemistry phenomena that are working together to achieve this significant reduction in refueling outage doses.
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Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
… alpha therapy. The fundamental chemistry and radiochemistry involved in the synthesis, purification and characterization of both [203Pb]Pb-RM2 and [212Pb]Pb-RM2 is described. Additionally, in vivo preclinical evaluation of the radiolabeled peptide conjugates was performed in male mouse models …
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Development of new radiopharmaceuticals targeting the Cholecystokinin 2 receptor
… alla pubblicazione scientifica sulla rivista Radiochemistry journal dal titolo “Cyclotron for PET: System Upgrade after 13 Years of Service” ed alla presentazione orale dal titolo “Cyclotron upgrade and New Research Labs at Cannizzaro Hospital” al congresso internazionale “IBA PET Users …
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Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis
… of oncology and neuroscience. The aim of the Radiochemistry On Chip (ROC) project was to develop such an integrated lab-on-chip device and, in particular, here results for on-chip pre-concentration of fluoride, together with some preliminary results on the removal of Kryptofix (K2.2.2) and the …
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I. Development of novel silicon precursors for rapid and efficient radiofluorination reactions: synthesis and biological evaluation of a 18f-labelled estrogen dendrimer conjugate II. Other studies on 18f-labelled estrogens
… Additionally, the basics of PET principles and radiochemistry are introduced, with a significant focus on the synthetic difficulties involved in working with the most commonly used PET isotope, fluorine-18, and why there is a need for improved methodology for its incorporation into new …
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Interference Effects of Urban Rubble on the Radioanalytical Analysis of Strontium
<p>Most current radioanalytical protocols have been developed for the analysis of air, water, soil and bioassay samples. While these protocols build the foundation of operational environmental monitoring, they are not necessarily suitable for the analysis of samples that will be encountered in the …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
<p>The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from …
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Separation of fission products from irradiated uranium by peroxide precipitation
<p>Aqueous precipitation of uranium as the peroxide has been used as a purification procedure since the early days of the Manhattan Project. The procedure has successfully produced an extremely pure product when handled in small batches. Heretofore peroxide precipitation has been utilized for …
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IR laser photochemistry of alkanols and 3,3-dimethyloxetane
In this work, a pulsed CO₂ laser was used to excite methanol, ethanol, propan-2-ol, butan-2-ol, t-butanol, pentan-2-ol, hexan-2-ol, and 3,3-dimethyloxetane in order to study how these moleCUles absorb laser energy and decompose. The dependence of absorbed energy and fractional yield on laser …
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Development of Radiochemical Quality Control Methods for Ra-223 and Th-227 Radiotherapies
<p><strong>Introduction.</strong> Radiolabeled molecules for use in disease detection and targeted treatment are a mainstay of patient management. The majority of radiopharmaceuticals deployed to date undergo a single radioactive transition (decay) to reach a stable ground state. Complex emitters, …
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Development of A Multi-Purpose Automated Synthesis Module For Production of Novel Pet Radiopharmaceuticals
<p>Among radiopharmaceuticals of positron emission tomography (PET), <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) made from commercialized automated synthesis module is the most frequently used in tumor diagnoses. But the false positive findings, such as infectious tissues and …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
SPECT and PET are non-invasive imaging techniques in which radiotracers are used to study biochemical and physiological functions in the living brain. In vivo brain mapping with PET or SPECT can be of great importance in drug development as well as in the effective diagnosis, treatment and …
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Development of New Radiolabeling Methods and Insights on Ionizing Radiation Interactions with Nanoparticles
<p>Nanoparticles are often combined with radionuclides for various applications, ranging from waste remediation to imaging and therapy in the medical field. The overarching aim of this body of work is two-fold. The first aim is development of new radiolabeling methods for various nanoparticles that …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
<p>The high specificity and affinity of antibodies make them attractive for developing drugs to diagnose and treat cancer. The overarching goal of this work is to explore the synthesis and use of antibody-based imaging agents in preclinical models of cancer. This work can be described as two-fold. …
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