FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING

Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2018

Author dc:creator

• Warner, Harleigh Jane

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/92380

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/92380