{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/92380"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/92380","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING","abstract":"Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting","abstract_html":"Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (&lt; 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting","abstract_has_math":false,"creators":["Warner, Harleigh Jane"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-27T22:02:23Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/92380","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Warner, Harleigh Jane"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-08-23T08:35:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2019-08-22T08:30:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/92380"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting"]},{"key":"dc:title","label":"Title","values":["FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING"]}]}],"canonical_facts":{"dc:creator":["Warner, Harleigh Jane"],"dc:date.accessioned":["2018-08-23T08:35:38Z"],"dc:date.available":["2019-08-22T08:30:13Z"],"dc:date.issued":["2018"],"dc:description.abstract":["Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting"],"dc:identifier.uri":["http://hdl.handle.net/10339/92380"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:title":["FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:23Z"}