UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY

Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2017

Author dc:creator

• Poole, Thomas

• Click

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/82253

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/82253