{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/82253"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/82253","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY","abstract":"Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation.","abstract_html":"Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation.","abstract_has_math":false,"creators":["Poole, Thomas"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017","date_published":"2017","updated_at":"2026-07-27T22:02:11Z","subjects":["Click"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/82253","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Poole, Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-06-15T08:36:18Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-06-14T08:30:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2017"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Click"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/82253"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation."]},{"key":"dc:title","label":"Title","values":["UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY"]}]}],"canonical_facts":{"dc:creator":["Poole, Thomas"],"dc:date.accessioned":["2017-06-15T08:36:18Z"],"dc:date.available":["2018-06-14T08:30:13Z"],"dc:date.issued":["2017"],"dc:description.abstract":["Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation."],"dc:identifier.uri":["http://hdl.handle.net/10339/82253"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Click"],"dc:title":["UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:11Z"}