FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS

The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2017

Author dc:creator

• Braco, Jason Thomas

• AKH

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/82158

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/82158