{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/82158"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/82158","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS","abstract":"The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.","abstract_html":"The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release.","abstract_has_math":false,"creators":["Braco, Jason Thomas"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017","date_published":"2017","updated_at":"2026-07-27T22:02:05Z","subjects":["AKH"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/82158","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Braco, Jason Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-06-15T08:35:27Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-12-30T09:30:14Z"]},{"key":"dc:date.issued","label":"Date","values":["2017"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["AKH"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/82158"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release."]},{"key":"dc:title","label":"Title","values":["FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS"]}]}],"canonical_facts":{"dc:creator":["Braco, Jason Thomas"],"dc:date.accessioned":["2017-06-15T08:35:27Z"],"dc:date.available":["2021-12-30T09:30:14Z"],"dc:date.issued":["2017"],"dc:description.abstract":["The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. In Drosophila, the mobilization of energy is primarily controlled by the endocrine factor Adipokinetic Hormone (AKH). AKH function is critical for proper energy allocation under ad libitum conditions, and is particularly important for the physiological and behavioral response to metabolic stress. Animals lacking AKH display multiple stress phenotypes including increased lifespan under starvation and the absence of starvation-induced locomotion. Research has primarily focused on understanding the downstream targets of AKH action, however, little work has explored AKH cell physiology and the mechanisms that govern AKH release."],"dc:identifier.uri":["http://hdl.handle.net/10339/82158"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["AKH"],"dc:title":["FUNCTIONAL DISSECTION OF ADIPOKINETIC HORMONE PRODUCING CELLS"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:05Z"}