MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING

Alcoholism is a chronically relapsing disorder characterized by an inability to remain abstinent from alcohol for prolonged periods of time. One of the major factors contributing to relapse is the development of profound anxiety during abstinence. Our lab has previously demonstrated that chronic exposure to alcohol and subsequent withdrawal leads to long-term adaptations in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal related anxiogenesis and can be ameliorated by glutamatergic antagonists. However, it remains unclear how acute exposure to alcohol produces long-term changes in BLA glutamatergic transmission.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Gioia, Dominic Andrew

• Alcohol

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/64171

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/64171