Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity

Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Smelser, Amanda M.

• breast cancer cells

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/62632

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/62632