{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/62632"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/62632","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity","abstract":"Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration.","abstract_html":"Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration.","abstract_has_math":false,"creators":["Smelser, Amanda M."],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T22:02:05Z","subjects":["breast cancer cells"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/62632","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Smelser, Amanda M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-08-25T08:35:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-08-25T08:35:19Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["breast cancer cells"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/62632"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration."]},{"key":"dc:title","label":"Title","values":["Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity"]}]}],"canonical_facts":{"dc:creator":["Smelser, Amanda M."],"dc:date.accessioned":["2016-08-25T08:35:19Z"],"dc:date.available":["2016-08-25T08:35:19Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration."],"dc:identifier.uri":["http://hdl.handle.net/10339/62632"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["breast cancer cells"],"dc:title":["Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:05Z"}