Development of a Novel 3-Dimensional Testicular Organoid Model for the Study of Human Spermatogenesis and Gonadotoxicity In Vitro

Current methods for evaluating potential gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on the use of animal data. However, current gold standard in vivo functional assays in animals are limited in their human predictive capacity, and existing human in vitro models of testicular toxicity do not recapitulate the complex signaling interactions of the native tissue environment. The overall goal of this study was to develop, characterize, and evaluate a 3-dimensional (3D) human testis organoid culture system for use as both a novel predictive first tier drug-screening tool and as a model of human testicular function in vitro.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Pendergraft, Samuel Sparrow

• Human

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/59334

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/59334