Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"Drug Screening"”.
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High throughput optical sensor arrays for drug screening
In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable of detecting cellular ion flux in multi-well plate format. Optodes are …
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Direct drug screening and lipid profiling using ambient mass spectrometry
… has been used for two applications: (1) Direct drug abuse monitoring for forensic and therapeutic use and (2) Quick screening of antibiotics in food for the food safety. In addition to selecting proper paper substrates and solvents, the quantitative performance of paper spray has also been …
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Human lactate dehydrogenase heterogeneous biocatalyst for efficient anticancer drug screening
L'abstract è presente nell'allegato / the abstract is in the attachment
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Development of 3-d liver model for drug screening applications
The need for a an in vitro drug screening system that mimics the structural organization of natural liver for multi-functionality and maintenance of hepatocytes has become vital in the drug development process. The objective of this study was to engineer a three-dimensional (3-D) liver model using …
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Assessment of ion-selective optical nanosensors for drug screening applications
Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay system using optical nanosensors has recently been developed. This …
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Mechanical stiffness-defined matrices for stem cell research and drug screening
… platforms in biological research and drug development. In this thesis, commercialization aspects of these engineered matrices for stem cell research, cell culture and drug development markets are evaluated both in USA and in Singapore markets. Technological barriers, intellectual …
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Contactless Dielectrophoresis towards Drug Screening and Microdevice Development for Cell Sorting
… its potential as a rapid, non-biomarker-based drug screening platform. Specifically, low frequency contactless dielectrophoresis devices previously designed by Sano et al were used to extract the crossover frequency and specific membrane capacitance of early and late stage mouse ovarian surface …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… 109203X a potential lead compound to be used in drug development for PDAC treatment.
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… its inception to advance disease modeling and drug screening. This is especially true for tissues that are difficult to study due to tissue sensitivity and limited regenerative capacity, such as the heart. Previous work in stem cell-derived cardiac tissue has exploited how we can engineer …
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A high-throughput antiepileptic drug screening system based on chemically Induced zebrafish behavioral model
… system to screen new antiepileptic drug is built up. Chemically induced zebrafish larvae are used as a seizure model. The change in fishes' behavior patterns serves as an indicator of the fishes' nervous system condition. The design of the behavior data acquisition setup as well as …
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Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening
… Atezolizumab and pembrolizumab, two antibody drugs targeting the PD-L1/PD-1 pathway, have been approved by FDA in combination with chemo drugs for certain TNBC cases in 2019 and 2020, respectively. These facts reveal the feasibility of immunotherapy in treating breast cancer. However, …
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Engineering complex liver models for drug screening and infectious diseases: a biomaterials and co-culture perspective
… have many applications in disease modeling and drug screening. Micropatterned cocultures (MPCCs) of primary human hepatocytes (PHHs) and supportive stromal cells have been shown to display high hepatic functions for long-term drug and disease studies. However, MPCCs lack liver non-parenchymal …
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Expanding the Capabilities of Paper Spray Mass Spectrometry: High-Throughput Drug Screening and On-Paper Electrokinetic Stacking
… through an automated high-throughput urine drug screening method. Chapter 3 investigates the negative impact of laser cutting paper spray substrates on sensitivity and provides practical remedies. The core of this work revolves around the development and application of electrokinetic …
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Investigating the clinical value of hyperactivation and intracellular calcium signalling of human spermatozoa and their value in drug screening
Confidential thesis. Abstract and full text under embargo until 12/03/2015.
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A Variational Lower Bound to Mitigate Batch Effect in Molecular Representations
High-throughput drug screening – using cell imaging or gene expression measurements as readouts of drug effect – is a critical tool in biotechnology to assess and understand the relationship between the chemical structure and biological activity of a drug. Since large-scale screens have to be …
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Generation of a Medaka Fish Model of Propionic Acidemia for Development of Novel Therapies.
… is suitable for rapid investigation of novel drugs by large-scale drug screening. I have set a drug screening assay on whole fishes using the clinically relevant locomotor activity as read-out of the assay. This large drug screening has the potential to lead to the identification of small …
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3D Cell Culture in Microgels: A Novel Screening Platform for Disease Modelling and Drug Testing
… of cancer. However, only 7% of new anti-cancer drugs make it through clinical trials and are brought to the market. This low success rate has been attributed to a lack of relevant cancer models. New drug candidates are usually tested on 2D cancer cell lines adhered to a plastic surface, which …
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Development of a methodology for applying shear stress to suspended mammalian cells
… affects their downstream applications, including drug screening and tissue regeneration. Current methods of loading shear stress onto suspended cells can be divided into three categories: (1) tubular shear equipment, (2) flow channel devices and (3) rheometer shear instruments. However, none of …
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In vivo identification of drug therapeutics for nemaline myopathy
… study employs the DiscoveryProbeTM FDA-approved drug library to perform a small molecule high-throughput drug screen as a strategy for developing therapies for Nemaline Myopathy (NM). Nemaline myopathy is a rare congenital neuromuscular disorder characterized by muscle weakness and the …
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Development of a Novel 3-Dimensional Testicular Organoid Model for the Study of Human Spermatogenesis and Gonadotoxicity In Vitro
… for use as both a novel predictive first tier drug-screening tool and as a model of human testicular function in vitro.
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