PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES

Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag).

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• McKay, Jerome Thomas

• B-1 cells

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/59291

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/59291