{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/59291"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/59291","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES","abstract":"Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag).","abstract_html":"Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag).","abstract_has_math":false,"creators":["McKay, Jerome Thomas"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T22:01:58Z","subjects":["B-1 cells"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/59291","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["McKay, Jerome Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-05-21T08:35:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-05-04T08:30:12Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["B-1 cells"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/59291"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag)."]},{"key":"dc:title","label":"Title","values":["PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES"]}]}],"canonical_facts":{"dc:creator":["McKay, Jerome Thomas"],"dc:date.accessioned":["2016-05-21T08:35:41Z"],"dc:date.available":["2021-05-04T08:30:12Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag)."],"dc:identifier.uri":["http://hdl.handle.net/10339/59291"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["B-1 cells"],"dc:title":["PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}