Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis

Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Metzler, Marnie Silverstein

• atherosclerosis

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/59263

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/59263