{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/59263"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/59263","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis","abstract":"Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression.","abstract_html":"Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression.","abstract_has_math":false,"creators":["Metzler, Marnie Silverstein"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T22:01:58Z","subjects":["atherosclerosis"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/59263","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Metzler, Marnie Silverstein"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-05-21T08:35:29Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-05-21T08:35:29Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["atherosclerosis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/59263"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression."]},{"key":"dc:title","label":"Title","values":["Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis"]}]}],"canonical_facts":{"dc:creator":["Metzler, Marnie Silverstein"],"dc:date.accessioned":["2016-05-21T08:35:29Z"],"dc:date.available":["2016-05-21T08:35:29Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression."],"dc:identifier.uri":["http://hdl.handle.net/10339/59263"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["atherosclerosis"],"dc:title":["Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}