Single Fibrin Fiber Mechanical Properties and Lysis

Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• LI, WEI

• fibrin fiber

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57266

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57266