{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/57266"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/57266","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Single Fibrin Fiber Mechanical Properties and Lysis","abstract":"Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states.","abstract_html":"Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states.","abstract_has_math":false,"creators":["LI, WEI"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-27T22:01:58Z","subjects":["fibrin fiber"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/57266","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["LI, WEI"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-08-25T08:35:35Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-08-24T08:30:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["fibrin fiber"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/57266"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states."]},{"key":"dc:title","label":"Title","values":["Single Fibrin Fiber Mechanical Properties and Lysis"]}]}],"canonical_facts":{"dc:creator":["LI, WEI"],"dc:date.accessioned":["2015-08-25T08:35:35Z"],"dc:date.available":["2017-08-24T08:30:13Z"],"dc:date.issued":["2015"],"dc:description.abstract":["Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states."],"dc:identifier.uri":["http://hdl.handle.net/10339/57266"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["fibrin fiber"],"dc:title":["Single Fibrin Fiber Mechanical Properties and Lysis"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}