CHARACTERIZING THE MICRO-SCALE MECHANICAL PROPERTIES OF HYDROGELS AND CANCER CELLS

Tissue engineering strategies nowadays require attention to not only cells, but also to the mechanical properties of the extracellular matrix (ECM).We studied the elasticity of hydrogels formulations frequently used in cell and tissue culturing. A variety of concentrations in a variety of biomaterials, including agarose, alginate, the collagens, fibrin, hyaluronic acid, kerateine, laminin, Matrigel, and polyethylene glycol diacrylate (PEGDA), were tested with atomic force microscopy (AFM). We also determined the Young’s modulus (E) of hydrogels with different concentrations. E tended to increase with increased concentration.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Guo, Xinyi

• Atomic Force Microscopy

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57120

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57120