Kinetic and mutational studies of two RNA-interacting enzymes

Cellular enzymes interact with RNA substrates at several key stages in an organism's life cycle, particularly during the processes of transcription and translation. A more detailed description of enzyme mechanistic features and kinetic parameters is important both for understanding molecular function in general and as possible therapeutic targets. The two classes of RNA-interacting enzymes investigated in the work described here are helicases, which disrupt RNA secondary structure, and aminoacyl-tRNA synthetases, which catalyze the attachment of an amino acid to its cognate tRNA.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2011

Author dc:creator

• Casina, Veronica Christine

• Pre-steady state kinetics

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/36429

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/36429