MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS

The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2011

Author dc:creator

• Nguyen, Tam Minh

• ABCG5/G8

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/36144

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/36144