{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/36144"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/36144","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS","abstract":"The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification.","abstract_html":"The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification.","abstract_has_math":false,"creators":["Nguyen, Tam Minh"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":["ABCG5/G8"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/36144","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Nguyen, Tam Minh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-09-08T08:35:47Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-09-08T08:30:06Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ABCG5/G8"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/36144"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification."]},{"key":"dc:title","label":"Title","values":["MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS"]}]}],"canonical_facts":{"dc:creator":["Nguyen, Tam Minh"],"dc:date.accessioned":["2011-09-08T08:35:47Z"],"dc:date.available":["2012-09-08T08:30:06Z"],"dc:date.issued":["2011"],"dc:description.abstract":["The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification."],"dc:identifier.uri":["http://hdl.handle.net/10339/36144"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["ABCG5/G8"],"dc:title":["MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}