PASSS: Protein Active Site Structure Search

The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within the body. A protein's function is defined by its active site, the area of the protein structure involved in the chemistry of its function. Because a protein's structure is related to its sequence, there currently exist many methods which compare protein sequences in an attempt to extrapolate function. Although effective for specific cases, there exist many documented instances where two proteins have similar structure and function, but dissimilar sequences. This occurs because structure determines the functionality of the protein, not the sequence.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2006

Author dc:creator

• Pryor, Edward E.

• Parallel Programming

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/33417

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/33417