Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Human Genome Project"”.
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Arguing the Genome: A Topology of the Argumentation Behind the Construction of the Human Genome Project
The Human Genome Project (HGP), the name given to the scientific program to map and decode all of human genetic material, has been projected to revolutionize the conduct of biological science in the twenty-first century. For several years before its formation in 1990, a federally-funded, systematic …
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The ELSI Research Program and Genetic Nondiscrimination Legislation: A Study in Science and Public Poilicy
The Human Genome Project, a multi-national initiative to map and sequence the entire human genome, is expected to reach completion in the year 2003. One of the more immediate and direct results of this remarkable scientific effort is an increase in both the number and range of genetic tests …
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Computational verification of published human mutations
The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse sequence variation and relate this information to important phenotypes. …
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PASSS: Protein Active Site Structure Search
The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within …
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Needs Analysis of Genetics and Genomics in Communication Sciences and Its Disorders: Evidence for Change
Purpose: Signaled by the completion of the Human Genome Project in 2003, rapid and escalating discovery in genome science has initiated a paradigm shift in education training and healthcare practices. This shift has required healthcare educators and professionals to possess a level of genetic and …
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The DNA of a high-performing manufacturing organization : improving operations capability through performance measurement
… contains the world's highest-throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project (HGP) completed in 2003. Broad's Genome Sequencing Operations Group has acquired a cost leadership position within the genome sequencing …
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Genetic Sequencing in Healthy Populations
After the success of the Human Genome Project, genetic sequencing technology has improved exponentially. Consumers can now have parts of their genome sequenced for under $100. Genetic sequencing in this direct-to-consumer (DTC) setting comes with many ethical problems that, despite being brought to …
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Graphene supported hafnium oxide nanopores for DNA sensing
The completion of the Human Genome Project in 2001 has served as both an inspiration and a challenge for researchers in the past decade. Understanding the genetic makeup of organisms is crucial for early disease detection, one of the driving forces behind personalized medicine. In this work, …
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Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
… system and its data. Due to its use in the human genome project (HGP), ABI has established a monopolistic position in the DNA-sequencing tool industry. As the de-facto standard of DNA sequencers ABI3730xl is highly automated, well-optimized, and black-boxed, despite the importance of higher …
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Owning the code of life : human gene patents in America
… Genetics. The case asked one question: are human genes patentable? Gene patents became commonplace during the biotechnology revolution of the 1980s, but generated a complex web of moral, legal, and biological questions. While some viewed gene patents as necessary in promoting and sustaining …
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Enabling sample tracking in and reducing variability in DNA library construction
… The Institute gained prominence during the Human Genome Project and has continued to be the nation's leading public laboratory for genomic sequencing projects. The Broad Institute has done this by taking advantage of economies of scale, rapid process innovation, and new process …
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Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
… contains the world's largest high throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project (HGP) completed in 2003. The Molecular Biology Production Group (MBPG) is the most upstream part of the Broad Institute's genome …
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Innovation in the life sciences : the impact of intellectual property rights on scientific knowledge diffusion, accumulation and utilization
… conditions. I take as my research setting, the Human Genome Project (HGP) and our mapping of the entire human genome that emerged from the project (as defined in both scientific publications and patents). The HGP was a 13-year, $3.8 billion research effort funded and coordinated by the U.S. …
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Covalent end-immobilization of oligonucleotides onto solid surfaces
With the completion of the Human Genome Project, the focus of genetics research has shifted towards functional genomics, with emphasis on gene expression and polymorphism studies. To this end, there is rapidly increasing interest in solid-phase, high-throughput, combinatorial microarrays for DNA …
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Genome data analysis, protein function and structure prediction by machine learning techniques
The raw information of a typical human genome has been generated at 2001 by Human Genome Project. However, since there are a huge amount of data, it is still a big challenge for people to understand them, and extract useful structure and function information, such as the function of genes, the …
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Massenspektrometrische Untersuchung posttranslationaler Modifikationen
… des menschlichen Genoms im Rahmen des „Human Genome Project“ sind sich die Experten einig, dass die Forschung sich nun den Vorgängen der komplexen Regulationsnetzwerken auf der Proteinebene widmen muß. Die Proteomforschung bedient sich dabei der möglichst optimalen und quantitativen …
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A contemporary history of the origins and development of UK Biobank, 1998-2005
… was set up following the completion of the Human Genome Project in 2001, and was one of many established at around the same time with the goal of translating the knowledge of the human genome sequence into practical benefits for human health. (National genetic databases were also set up or …
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Organizational Antecedents to the Implementation of Precision Medicine: Overcoming Resistance to Change
… to transform clinical practice in 2003 when the Human Genome Project reached completion but resistance to implementation at virtually all health care providers provides the basis for novel study on the diffusion of innovation as well as operational strategy. Existing studies on resistance to PM …
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New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional Integration
… available genomic information resulted from the Human Genome Project (HGP) and the increasing usage of high throughput technology. HGP was completed in 2003 and resulted in identifying 20,000-25,000 genes in human DNA and determining the sequences of three billion human base pairs. The …
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Information theoretic and machine learning techniques for emerging genomic data analysis
"The completion of the Human Genome Project in 2003 opened a new era for scientists. Through advanced high-throughput sequencing technologies, we now have access to a large amount of genomic data and we can use it to answer key biological questions, such as the factors contributing to the …
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